Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder
Response inhibition is an executive function that requires voluntary control over responses when there is a change of context. The right inferior frontal cortex is necessary for response inhibition, and a deficit in right frontostriatal circuitry might underlie attention-deficit/hyperactivity disord...
Gespeichert in:
| Veröffentlicht in: | Biological psychiatry (1969) 2003-12, Vol.54 (12), p.1465-1468 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1468 |
|---|---|
| container_issue | 12 |
| container_start_page | 1465 |
| container_title | Biological psychiatry (1969) |
| container_volume | 54 |
| creator | Aron, Adam R Dowson, Jonathon H Sahakian, Barbara J Robbins, Trevor W |
| description | Response inhibition is an executive function that requires voluntary control over responses when there is a change of context. The right inferior frontal cortex is necessary for response inhibition, and a deficit in right frontostriatal circuitry might underlie attention-deficit/hyperactivity disorder (ADHD). Many studies of childhood ADHD have demonstrated impaired response inhibition and its amelioration by methylphenidate (MPH). The current study tested response inhibition and the effect of MPH in adult ADHD.
Response inhibition was assessed with the “tracking” stop-signal test in 13 adults with a diagnosis of ADHD, both while taking and while not taking medication, and 13 healthy, unmedicated, age- and intelligence quotient–matched control subjects.
Stop-signal reaction time was significantly slower in unmedicated adults with ADHD relative to healthy control subjects, and this deficit was significantly ameliorated by medication.
Adult ADHD patients had a response inhibition profile similar to that produced by lesions to the right inferior frontal cortex, which was remedied by stimulant medication. |
| doi_str_mv | 10.1016/S0006-3223(03)00609-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71473303</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006322303006097</els_id><sourcerecordid>71473303</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-b3841ed0fae355e5472139e2b886b4d793964cef799603a467614ebca7de1a783</originalsourceid><addsrcrecordid>eNqFkN9P2zAQgK0JRAvjTxjKCxN7CPWvxMkTmhAbSEV72Hi2HPui3JQmwXaL-t_j0mp9nHSSz77vbN9HyBdGbxll5eI3pbTMBefihopvKad1rj6ROauUyLmk_ITM_yEzch7C37RVnLMzMmOyVEXF-Jy4Z4jdtp86GNCZCBmuJj9uIGQewjQOIZ0MHTYYcRxSmhm37mPI3jB2mYkRhl0hd9CixbjothN4YyNuMG4zh2H0DvxnctqaPsDlYb0gLz8e_tw_5stfP5_uvy9zK6WIeSMqycDR1oAoCiik4kzUwJuqKhvpVC3qUlpoVV2XVJg0Q8kkNNYoB8yoSlyQr_t70wivawhRrzBY6HszwLgOWjGphKAigcUetH4MwUOrJ48r47eaUb3Tqz_06p07TVPs9GqV-q4OD6ybFbhj18FnAq4PgAnW9K03g8Vw5ApR1EVNE3e35yDp2CB4HSzCYMGhBxu1G_E_X3kHOn2Y7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71473303</pqid></control><display><type>article</type><title>Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Aron, Adam R ; Dowson, Jonathon H ; Sahakian, Barbara J ; Robbins, Trevor W</creator><creatorcontrib>Aron, Adam R ; Dowson, Jonathon H ; Sahakian, Barbara J ; Robbins, Trevor W</creatorcontrib><description>Response inhibition is an executive function that requires voluntary control over responses when there is a change of context. The right inferior frontal cortex is necessary for response inhibition, and a deficit in right frontostriatal circuitry might underlie attention-deficit/hyperactivity disorder (ADHD). Many studies of childhood ADHD have demonstrated impaired response inhibition and its amelioration by methylphenidate (MPH). The current study tested response inhibition and the effect of MPH in adult ADHD.
Response inhibition was assessed with the “tracking” stop-signal test in 13 adults with a diagnosis of ADHD, both while taking and while not taking medication, and 13 healthy, unmedicated, age- and intelligence quotient–matched control subjects.
Stop-signal reaction time was significantly slower in unmedicated adults with ADHD relative to healthy control subjects, and this deficit was significantly ameliorated by medication.
Adult ADHD patients had a response inhibition profile similar to that produced by lesions to the right inferior frontal cortex, which was remedied by stimulant medication.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(03)00609-7</identifier><identifier>PMID: 14675812</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Biological and medical sciences ; Case-Control Studies ; Central Nervous System Stimulants - therapeutic use ; Executive function ; frontal cortex ; Humans ; impulsivity ; Inhibition (Psychology) ; Intelligence - drug effects ; Intelligence Tests ; Male ; Medical sciences ; Methylphenidate - therapeutic use ; Miscellaneous ; Neuropsychological Tests ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - drug effects ; Psychopathology. Psychiatry ; Reaction Time - drug effects ; right hemisphere ; stimulant drugs ; stop-signal ; Time Factors</subject><ispartof>Biological psychiatry (1969), 2003-12, Vol.54 (12), p.1465-1468</ispartof><rights>2003 Society of Biological Psychiatry</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-b3841ed0fae355e5472139e2b886b4d793964cef799603a467614ebca7de1a783</citedby><cites>FETCH-LOGICAL-c443t-b3841ed0fae355e5472139e2b886b4d793964cef799603a467614ebca7de1a783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(03)00609-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15359590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14675812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aron, Adam R</creatorcontrib><creatorcontrib>Dowson, Jonathon H</creatorcontrib><creatorcontrib>Sahakian, Barbara J</creatorcontrib><creatorcontrib>Robbins, Trevor W</creatorcontrib><title>Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Response inhibition is an executive function that requires voluntary control over responses when there is a change of context. The right inferior frontal cortex is necessary for response inhibition, and a deficit in right frontostriatal circuitry might underlie attention-deficit/hyperactivity disorder (ADHD). Many studies of childhood ADHD have demonstrated impaired response inhibition and its amelioration by methylphenidate (MPH). The current study tested response inhibition and the effect of MPH in adult ADHD.
Response inhibition was assessed with the “tracking” stop-signal test in 13 adults with a diagnosis of ADHD, both while taking and while not taking medication, and 13 healthy, unmedicated, age- and intelligence quotient–matched control subjects.
Stop-signal reaction time was significantly slower in unmedicated adults with ADHD relative to healthy control subjects, and this deficit was significantly ameliorated by medication.
Adult ADHD patients had a response inhibition profile similar to that produced by lesions to the right inferior frontal cortex, which was remedied by stimulant medication.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Attention Deficit Disorder with Hyperactivity - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Central Nervous System Stimulants - therapeutic use</subject><subject>Executive function</subject><subject>frontal cortex</subject><subject>Humans</subject><subject>impulsivity</subject><subject>Inhibition (Psychology)</subject><subject>Intelligence - drug effects</subject><subject>Intelligence Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylphenidate - therapeutic use</subject><subject>Miscellaneous</subject><subject>Neuropsychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time - drug effects</subject><subject>right hemisphere</subject><subject>stimulant drugs</subject><subject>stop-signal</subject><subject>Time Factors</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN9P2zAQgK0JRAvjTxjKCxN7CPWvxMkTmhAbSEV72Hi2HPui3JQmwXaL-t_j0mp9nHSSz77vbN9HyBdGbxll5eI3pbTMBefihopvKad1rj6ROauUyLmk_ITM_yEzch7C37RVnLMzMmOyVEXF-Jy4Z4jdtp86GNCZCBmuJj9uIGQewjQOIZ0MHTYYcRxSmhm37mPI3jB2mYkRhl0hd9CixbjothN4YyNuMG4zh2H0DvxnctqaPsDlYb0gLz8e_tw_5stfP5_uvy9zK6WIeSMqycDR1oAoCiik4kzUwJuqKhvpVC3qUlpoVV2XVJg0Q8kkNNYoB8yoSlyQr_t70wivawhRrzBY6HszwLgOWjGphKAigcUetH4MwUOrJ48r47eaUb3Tqz_06p07TVPs9GqV-q4OD6ybFbhj18FnAq4PgAnW9K03g8Vw5ApR1EVNE3e35yDp2CB4HSzCYMGhBxu1G_E_X3kHOn2Y7A</recordid><startdate>20031215</startdate><enddate>20031215</enddate><creator>Aron, Adam R</creator><creator>Dowson, Jonathon H</creator><creator>Sahakian, Barbara J</creator><creator>Robbins, Trevor W</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031215</creationdate><title>Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder</title><author>Aron, Adam R ; Dowson, Jonathon H ; Sahakian, Barbara J ; Robbins, Trevor W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-b3841ed0fae355e5472139e2b886b4d793964cef799603a467614ebca7de1a783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Attention Deficit Disorder with Hyperactivity - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Central Nervous System Stimulants - therapeutic use</topic><topic>Executive function</topic><topic>frontal cortex</topic><topic>Humans</topic><topic>impulsivity</topic><topic>Inhibition (Psychology)</topic><topic>Intelligence - drug effects</topic><topic>Intelligence Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylphenidate - therapeutic use</topic><topic>Miscellaneous</topic><topic>Neuropsychological Tests</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychopathology. Psychiatry</topic><topic>Reaction Time - drug effects</topic><topic>right hemisphere</topic><topic>stimulant drugs</topic><topic>stop-signal</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aron, Adam R</creatorcontrib><creatorcontrib>Dowson, Jonathon H</creatorcontrib><creatorcontrib>Sahakian, Barbara J</creatorcontrib><creatorcontrib>Robbins, Trevor W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aron, Adam R</au><au>Dowson, Jonathon H</au><au>Sahakian, Barbara J</au><au>Robbins, Trevor W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2003-12-15</date><risdate>2003</risdate><volume>54</volume><issue>12</issue><spage>1465</spage><epage>1468</epage><pages>1465-1468</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Response inhibition is an executive function that requires voluntary control over responses when there is a change of context. The right inferior frontal cortex is necessary for response inhibition, and a deficit in right frontostriatal circuitry might underlie attention-deficit/hyperactivity disorder (ADHD). Many studies of childhood ADHD have demonstrated impaired response inhibition and its amelioration by methylphenidate (MPH). The current study tested response inhibition and the effect of MPH in adult ADHD.
Response inhibition was assessed with the “tracking” stop-signal test in 13 adults with a diagnosis of ADHD, both while taking and while not taking medication, and 13 healthy, unmedicated, age- and intelligence quotient–matched control subjects.
Stop-signal reaction time was significantly slower in unmedicated adults with ADHD relative to healthy control subjects, and this deficit was significantly ameliorated by medication.
Adult ADHD patients had a response inhibition profile similar to that produced by lesions to the right inferior frontal cortex, which was remedied by stimulant medication.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14675812</pmid><doi>10.1016/S0006-3223(03)00609-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 2003-12, Vol.54 (12), p.1465-1468 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71473303 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Adult and adolescent clinical studies Attention Deficit Disorder with Hyperactivity - drug therapy Biological and medical sciences Case-Control Studies Central Nervous System Stimulants - therapeutic use Executive function frontal cortex Humans impulsivity Inhibition (Psychology) Intelligence - drug effects Intelligence Tests Male Medical sciences Methylphenidate - therapeutic use Miscellaneous Neuropsychological Tests Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopathology. Psychiatry Reaction Time - drug effects right hemisphere stimulant drugs stop-signal Time Factors |
| title | Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T06%3A58%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methylphenidate%20improves%20response%20inhibition%20in%20adults%20with%20attention-deficit/hyperactivity%20disorder&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=Aron,%20Adam%20R&rft.date=2003-12-15&rft.volume=54&rft.issue=12&rft.spage=1465&rft.epage=1468&rft.pages=1465-1468&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/S0006-3223(03)00609-7&rft_dat=%3Cproquest_cross%3E71473303%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71473303&rft_id=info:pmid/14675812&rft_els_id=S0006322303006097&rfr_iscdi=true |