Estrogenic hormone action in the heart: regulatory network and function
Cardiovascular diseases are the leading cause of death in the industrialised countries and display significant gender-based differences. Estrogen plays an important role in the pathogenesis of heart disease and is able to modulate the progression of cardiovascular disease. The focus on the beneficia...
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| Veröffentlicht in: | Cardiovascular research 2002-02, Vol.53 (3), p.709-719 |
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| container_issue | 3 |
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| container_title | Cardiovascular research |
| container_volume | 53 |
| creator | BABIKER, Fawzi A DE WINDT, Leon J VAN EICKELS, Martin GROHE, Christian MEYER, Rainer DOEVENDANS, Pieter A |
| description | Cardiovascular diseases are the leading cause of death in the industrialised countries and display significant gender-based differences. Estrogen plays an important role in the pathogenesis of heart disease and is able to modulate the progression of cardiovascular disease. The focus on the beneficial influence of estrogen is gradually shifting from the vascular system to the myocardium. The presence of functional estrogen receptors in the myocardium has been demonstrated. Estrogen is important for cardiovascular baseline physiology and modulates the myocardial response under pathological conditions. Here we summarise the current knowledge of the regulatory network of estrogenic action in the myocardium and its effects on cardiovascular function. |
| doi_str_mv | 10.1016/s0008-6363(01)00526-0 |
| format | Article |
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Vascular system</subject><subject>Cardiomegaly - metabolism</subject><subject>Cardiomyopathies - metabolism</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary heart disease</subject><subject>Estrogen Receptor alpha</subject><subject>Estrogen Receptor beta</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens - genetics</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Heart</subject><subject>Heart Failure - metabolism</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Myocardium - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Signal Transduction</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLxDAQwPEgiq6Pj6DkouihmmlerTdZ1gcseFDPIabT3Wo30aRF_PZu16KnMPCbCfwJOQZ2CQzUVWKMFZniip8zuGBM5ipjW2QCWsqM50Juk8kf2SP7Kb2tRym12CV7AIUCJmBC7mapi2GBvnF0GeIqeKTWdU3wtPG0WyJdoo3dNY246FvbhfhNPXZfIb5T6yta936jD8lObduER-N7QF5uZ8_T-2z-ePcwvZlnToiiy2xpC25BWmQ5c6UUJVSoAayEWiHmRSlLjgxLp4Soc1WJV4e6yrkWWlZ5zQ_I2e_djxg-e0ydWTXJYdtaj6FPRoPQuZRsDeUvdDGkFLE2H7FZ2fhtgJmhoHka8pghj2FgNgXNsHcyftC_rrD63xqTrcHpCGxytq2j9a5J_45LDopr_gOkeXi6</recordid><startdate>20020215</startdate><enddate>20020215</enddate><creator>BABIKER, Fawzi A</creator><creator>DE WINDT, Leon J</creator><creator>VAN EICKELS, Martin</creator><creator>GROHE, Christian</creator><creator>MEYER, Rainer</creator><creator>DOEVENDANS, Pieter A</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020215</creationdate><title>Estrogenic hormone action in the heart: regulatory network and function</title><author>BABIKER, Fawzi A ; DE WINDT, Leon J ; VAN EICKELS, Martin ; GROHE, Christian ; MEYER, Rainer ; DOEVENDANS, Pieter A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-a9a83a15ae020c95491de711a51f6ee289593e0e9c644f26d4bce7d237475d2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. 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| ispartof | Cardiovascular research, 2002-02, Vol.53 (3), p.709-719 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Cardiology. Vascular system Cardiomegaly - metabolism Cardiomyopathies - metabolism Coronary Disease - metabolism Coronary heart disease Estrogen Receptor alpha Estrogen Receptor beta Estrogen Replacement Therapy Estrogens - genetics Estrogens - physiology Female Gene Expression Heart Heart Failure - metabolism Hemodynamics Humans Medical sciences Myocardium - metabolism Receptors, Estrogen - metabolism Signal Transduction |
| title | Estrogenic hormone action in the heart: regulatory network and function |
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