Mechanical Regulation of Mitogen-activated Protein Kinase Signaling in Articular Cartilage

Articular chondrocytes respond to mechanical forces by alterations in gene expression, proliferative status, and metabolic functions. Little is known concerning the cell signaling systems that receive, transduce, and convey mechanical information to the chondrocyte interior. Here, we show that ex vi...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (51), p.50940-50948
Hauptverfasser:	Fanning, Paul J., Emkey, Gregory, Smith, Robert J., Grodzinsky, Alan J., Szasz, Nora, Trippel, Stephen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biomechanical Phenomena Cartilage, Articular - metabolism Cattle Insulin-Like Growth Factor I - physiology JNK Mitogen-Activated Protein Kinases MAP Kinase Signaling System - physiology Mechanotransduction, Cellular - physiology Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases Phosphorylation Time Factors
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