Differential involvement of Src family kinases in pervanadate-mediated responses in rat myometrial cells

We previously described that pervanadate, a potent tyrosine phosphatase inhibitor, induced contraction of rat myometrium via phospholipase (PL) C-γ1 activation [Biol Reprod 54 (1996) 1383]. In this study, we found that pervanadate induced tyrosine phosphorylation of the platelet-derived growth facto...

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Veröffentlicht in:	Cellular signalling 2002-04, Vol.14 (4), p.341-349
Hauptverfasser:	Boulven, Isaline, Robin, Philippe, Desmyter, Christine, Harbon, Simone, Leiber, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured DNA - biosynthesis Enzyme Inhibitors - pharmacology ERK Female Inositol Phosphates - biosynthesis Isoenzymes - metabolism Kinetics Mitogen-Activated Protein Kinases - metabolism Myometrium - drug effects Myometrium - enzymology Myometrium - metabolism PDGF Pervanadate Phospholipase C gamma Phosphorylation Phosphotyrosine - metabolism PLC-γ1 Protein Tyrosine Phosphatases - antagonists & inhibitors Proto-Oncogene Proteins pp60(c-src) - metabolism Rat myometrial cells Rats Rats, Wistar Receptor, Platelet-Derived Growth Factor beta - metabolism Signal Transduction - drug effects Src kinase Type C Phospholipases - metabolism Vanadates - pharmacology
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