Genome engineering reveals large dispensable regions in Bacillus subtilis

Bacterial genomes contain 250 to 500 essential genes, as suggested by single gene disruptions and theoretical considerations. If this view is correct, the remaining nonessential genes of an organism, such as Bacillus subtilis, have been acquired during evolution in its perpetually changing ecologica...

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Veröffentlicht in:	Molecular biology and evolution 2003-12, Vol.20 (12), p.2076-2090
Hauptverfasser:	Westers, Helga, Dorenbos, Ronald, van Dijl, Jan Maarten, Kabel, Jorrit, Flanagan, Tony, Devine, Kevin M, Jude, Florence, Seror, Simone J, Beekman, Aaron C, Darmon, Elise, Eschevins, Caroline, de Jong, Anne, Bron, Sierd, Kuipers, Oscar P, Albertini, Alessandra M, Antelmann, Haike, Hecker, Michael, Zamboni, Nicola, Sauer, Uwe, Bruand, Claude, Ehrlich, Dusko S, Alonso, Juan C, Salas, Margarita, Quax, Wim J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus Phages - genetics Bacillus Phages - growth & development Bacillus subtilis Bacillus subtilis - genetics Bacillus subtilis - growth & development Chromosomes, Bacterial Culture Media Escherichia coli - genetics Evolution, Molecular Gene Deletion Genetic Engineering - methods Genome, Bacterial Physical Chromosome Mapping Plasmids Spores, Bacterial - genetics
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