Differential Involvement of the Ras and Rap1 Small GTPases in Vasoactive Intestinal and Pituitary Adenylyl Cyclase Activating Polypeptides Control of the Prolactin Gene

In pituitary cells, transcriptional regulation of the prolactin (PRL) gene and prolactin secretion are controlled by multiple transduction pathways through the activation of G protein coupled receptors and receptor tyrosine kinases. In the somatolactotrope GH4C1 cell line, we have previously identif...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (51), p.51386-51394
Hauptverfasser:	Romano, David, Magalon, Karine, Ciampini, Audrey, Talet, Christine, Enjalbert, Alain, Gerard, Corinne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Epidermal Growth Factor - metabolism Gene Expression Regulation Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Neuropeptides - metabolism Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary Gland - cytology Prolactin - biosynthesis Prolactin - genetics Promoter Regions, Genetic rap1 GTP-Binding Proteins - metabolism rap1 GTP-Binding Proteins - physiology Rap1 protein Ras protein ras Proteins - metabolism ras Proteins - physiology Rats Receptors, Vasoactive Intestinal Peptide - metabolism Receptors, Vasoactive Intestinal Peptide, Type II Signal Transduction thyrotropin-releasing hormone Thyrotropin-Releasing Hormone - metabolism Transcription, Genetic Transcriptional Activation Vasoactive Intestinal Peptide - metabolism
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