Expression of angiogenic factors during distraction osteogenesis

Distraction osteogenesis is a unique and effective way to treat limb length inequality resulting from congenital and posttraumatic skeletal defects. However, despite its widespread clinical use, the cellular and molecular mechanisms by which this surgical treatment promotes new bone formation are no...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2003-12, Vol.33 (6), p.889-898
Hauptverfasser:	Pacicca, D.M, Patel, N, Lee, C, Salisbury, K, Lehmann, W, Carvalho, R, Gerstenfeld, L.C, Einhorn, T.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inducing Agents - metabolism Angiopoietins - genetics Animals Biological and medical sciences Bone morphogenetic protein Bone Morphogenetic Proteins - genetics Carrier Proteins - genetics Collagen - genetics Cytokines - genetics Distraction osteogenesis Extracellular matrix Femur - metabolism Femur - pathology Femur - surgery Fibroblast Growth Factor 2 - analysis Fibroblast Growth Factor 2 - genetics Fracture Healing - genetics Fracture Healing - physiology Gene Expression Gene Expression Profiling Hypoxia-Inducible Factor 1, alpha Subunit Immunohistochemistry Male Medical sciences mRNA expression Neovascularization, Physiologic - genetics Neuropilins - genetics Oligonucleotide Array Sequence Analysis Orthopedic surgery Osteocalcin - genetics Osteogenesis - genetics Osteogenesis, Distraction Osteopontin Rats Rats, Sprague-Dawley Receptor, Fibroblast Growth Factor, Type 4 Receptors, Fibroblast Growth Factor - genetics Receptors, TIE - genetics Receptors, Vascular Endothelial Growth Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sialoglycoproteins - genetics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transcription Factors - genetics Transforming Growth Factor beta - genetics Transforming Growth Factor beta2 Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factors - genetics von Willebrand Factor - analysis
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