Identification of G-proteins coupling to the vasoactive intestinal peptide receptor VPAC(1) using immunoaffinity chromatography: evidence for precoupling

VPAC(1) receptor subtype-specific G-protein interactions were identified using a strategy that exploits an essential initial signaling event, namely the functional and physical association of the receptor with G-protein. An immunoaffinity purification column was constructed using a previously charac...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-02, Vol.290 (4), p.1300-1307
1. Verfasser:	Martin Shreeve, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Line Chromatography, Affinity Cross-Linking Reagents GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Protein alpha Subunits, Gs - metabolism GTP-Binding Proteins - metabolism Heterotrimeric GTP-Binding Proteins - metabolism Humans Lung - metabolism Macromolecular Substances Rats Receptors, Vasoactive Intestinal Peptide - chemistry Receptors, Vasoactive Intestinal Peptide - immunology Receptors, Vasoactive Intestinal Peptide - metabolism Receptors, Vasoactive Intestinal Polypeptide, Type I Transfection
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