Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons
Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) speci...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2002-02, Vol.33 (4), p.559-571 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Wang, Jian Zugates, Christopher T Liang, Inray H Lee, Ching-Hsien J Lee, Tzumin |
| description | Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the
Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies. Single axon analysis further reveals that
Dscam mutant axons generate additional branches, which randomly segregate among the available targets. Moreover, when only one target remains, branching is suppressed in wild-type axons while
Dscam mutant axons still form multiple branches at the original bifurcation point. Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching. |
| doi_str_mv | 10.1016/S0896-6273(02)00570-6 |
| format | Article |
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Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies. Single axon analysis further reveals that
Dscam mutant axons generate additional branches, which randomly segregate among the available targets. Moreover, when only one target remains, branching is suppressed in wild-type axons while
Dscam mutant axons still form multiple branches at the original bifurcation point. Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(02)00570-6</identifier><identifier>PMID: 11856530</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Adhesion Molecules ; Cell Communication - genetics ; Cell Differentiation - genetics ; Central Nervous System - abnormalities ; Central Nervous System - metabolism ; Central Nervous System - pathology ; Choristoma - genetics ; Clone Cells - metabolism ; Clone Cells - pathology ; Cloning ; Drosophila melanogaster - cytology ; Drosophila melanogaster - embryology ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Embryonic Induction - genetics ; Female ; Ganglia, Invertebrate - abnormalities ; Ganglia, Invertebrate - metabolism ; Ganglia, Invertebrate - pathology ; Gene Expression Regulation, Developmental - physiology ; Genes, Reporter - genetics ; Growth Cones - metabolism ; Growth Cones - pathology ; Insects ; Male ; Microscopy ; Mutation ; Mutation - physiology ; Neurons ; Phenotype ; Proteins - genetics ; Proteins - metabolism</subject><ispartof>Neuron (Cambridge, Mass.), 2002-02, Vol.33 (4), p.559-571</ispartof><rights>2002 Cell Press</rights><rights>Copyright Elsevier Limited Feb 14, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-d893f5564940e9c1758faaf8edf5528470880137e5413f8b7e9f30ac5a037f9d3</citedby><cites>FETCH-LOGICAL-c519t-d893f5564940e9c1758faaf8edf5528470880137e5413f8b7e9f30ac5a037f9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0896627302005706$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11856530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Zugates, Christopher T</creatorcontrib><creatorcontrib>Liang, Inray H</creatorcontrib><creatorcontrib>Lee, Ching-Hsien J</creatorcontrib><creatorcontrib>Lee, Tzumin</creatorcontrib><title>Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the
Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies. Single axon analysis further reveals that
Dscam mutant axons generate additional branches, which randomly segregate among the available targets. Moreover, when only one target remains, branching is suppressed in wild-type axons while
Dscam mutant axons still form multiple branches at the original bifurcation point. Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching.</description><subject>Animals</subject><subject>Cell Adhesion Molecules</subject><subject>Cell Communication - genetics</subject><subject>Cell Differentiation - genetics</subject><subject>Central Nervous System - abnormalities</subject><subject>Central Nervous System - metabolism</subject><subject>Central Nervous System - pathology</subject><subject>Choristoma - genetics</subject><subject>Clone Cells - metabolism</subject><subject>Clone Cells - pathology</subject><subject>Cloning</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Embryonic Induction - genetics</subject><subject>Female</subject><subject>Ganglia, Invertebrate - abnormalities</subject><subject>Ganglia, Invertebrate - metabolism</subject><subject>Ganglia, Invertebrate - pathology</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Genes, Reporter - genetics</subject><subject>Growth Cones - metabolism</subject><subject>Growth Cones - pathology</subject><subject>Insects</subject><subject>Male</subject><subject>Microscopy</subject><subject>Mutation</subject><subject>Mutation - physiology</subject><subject>Neurons</subject><subject>Phenotype</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9rFDEQx4Mo9qz-CUpAEH1YnWw2v56k7VUtFARPn0OanVxT7jbbZLfof2-ud1TwpU9Dhs93hsyHkNcMPjJg8tMKtJGNbBV_D-0HAKGgkU_IgoFRTceMeUoWD8gReVHKDQDrhGHPyRFjWkjBYUHmZU4ljddx4-iyeLelF4X-wNs5ZuxpSJku4x3mNQ4TXeE649pNMQ00BbqKZcJMT7Mb_DUW6oaeruZxzFhKfZ77KY3R09MY5uwfUie_01BekmfBbQq-OtRj8uvL-c-zb83l968XZyeXjRfMTE2vDQ9CyM50gMYzJXRwLmjsa7fVnQKtgXGFomM86CuFJnBwXjjgKpieH5N3-7ljTrczlsluY_G42bgB01ysYp00AtSjINNcay134Nv_wJs056F-wjJRt0po2Y4Se8rX65aMwY45bl3-YxnYnT57r8_u3Fho7b0-K2vuzWH6fLXF_l_q4KsCn_cA1qvdRcy2-IiDx7768pPtU3xkxV_ny6mE</recordid><startdate>20020214</startdate><enddate>20020214</enddate><creator>Wang, Jian</creator><creator>Zugates, Christopher T</creator><creator>Liang, Inray H</creator><creator>Lee, Ching-Hsien J</creator><creator>Lee, Tzumin</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20020214</creationdate><title>Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons</title><author>Wang, Jian ; 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From a genetic mosaic screen, we find that a lethal mutation in the
Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies. Single axon analysis further reveals that
Dscam mutant axons generate additional branches, which randomly segregate among the available targets. Moreover, when only one target remains, branching is suppressed in wild-type axons while
Dscam mutant axons still form multiple branches at the original bifurcation point. Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11856530</pmid><doi>10.1016/S0896-6273(02)00570-6</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Adhesion Molecules Cell Communication - genetics Cell Differentiation - genetics Central Nervous System - abnormalities Central Nervous System - metabolism Central Nervous System - pathology Choristoma - genetics Clone Cells - metabolism Clone Cells - pathology Cloning Drosophila melanogaster - cytology Drosophila melanogaster - embryology Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryonic Induction - genetics Female Ganglia, Invertebrate - abnormalities Ganglia, Invertebrate - metabolism Ganglia, Invertebrate - pathology Gene Expression Regulation, Developmental - physiology Genes, Reporter - genetics Growth Cones - metabolism Growth Cones - pathology Insects Male Microscopy Mutation Mutation - physiology Neurons Phenotype Proteins - genetics Proteins - metabolism |
| title | Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons |
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