Molecular epidemiology of TTV-like mini virus in Norway

TT virus (TTV), the first human circovirus to be discovered, appears to be present in most people; less is known about the prevalence of the related TTV-like mini virus (TLMV). A sensitive nested PCR, specific for TLMV, detected the virus in 48% of 201 sera (Norwegian blood donors) previously found...

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Veröffentlicht in:	Archives of virology 2002, Vol.147 (1), p.181-185
Hauptverfasser:	MOEN, E. M, HUANG, L, GRINDE, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal viral diseases Biological and medical sciences Blood & organ donations Blood Donors Circoviridae Infections - epidemiology Circoviridae Infections - virology Circovirus - genetics Circovirus - isolation & purification Design DNA, Viral - blood Enzymes Epidemiology Fundamental and applied biological sciences. Psychology Humans Infectious diseases Medical sciences Microbiology Molecular Epidemiology Molecular Sequence Data Norway - epidemiology Polymerase chain reaction Sequence Analysis, DNA TT virus Viral diseases Virology Viruses
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Beschreibung
Zusammenfassung:	TT virus (TTV), the first human circovirus to be discovered, appears to be present in most people; less is known about the prevalence of the related TTV-like mini virus (TLMV). A sensitive nested PCR, specific for TLMV, detected the virus in 48% of 201 sera (Norwegian blood donors) previously found to have a 90% prevalence of TTV. More samples were either positive for both or negative for both viruses than what would have been expected from a random distribution (p = 0.08). Sequence analysis revealed considerable heterogeneity of Norwegian TLMV as compared to international sequences, suggesting that TLMV is efficiently dispersed in human populations.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s705-002-8310-6