Essential Role for Vascular Gelatinase Activity in Relaxin-Induced Renal Vasodilation, Hyperfiltration, and Reduced Myogenic Reactivity of Small Arteries

ABSTRACT—During pregnancy, relaxin stimulates nitric oxide (NO)–dependent renal vasodilation, hyperfiltration and reduced myogenic reactivity of small renal arteries via the endothelial ETB receptor subtype. Our objective in this study was to elucidate the mechanisms by which relaxin stimulates the...

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Veröffentlicht in:	Circulation research 2003-12, Vol.93 (12), p.1249-1257
Hauptverfasser:	Jeyabalan, Arundhathi, Novak, Jacqueline, Danielson, Lee A, Kerchner, Laurie J, Opett, Shannon L, Conrad, Kirk P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism Biological and medical sciences Dipeptides - pharmacology Endothelin-Converting Enzymes Female Fundamental and applied biological sciences. Psychology Gelatinases - antagonists & inhibitors Gelatinases - metabolism Gelatinases - physiology Glomerular Filtration Rate - drug effects Humans In Vitro Techniques Kidney - drug effects Kidney - physiology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 2 - physiology Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase 9 - physiology Matrix Metalloproteinase Inhibitors Metalloendopeptidases Oligopeptides - pharmacology Peptides, Cyclic - pharmacology Pregnancy Protease Inhibitors - pharmacology Rats Rats, Long-Evans Recombinant Proteins - pharmacology Relaxin - pharmacology Renal Artery - drug effects Renal Artery - physiology Vasodilation - drug effects Vertebrates: urinary system
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