Histologic features of Venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer
Pancreatic cancer frequently is associated with venous invasion and hematogenous metastasis. To determine morphologic features of invaded veins, intratumoral vascular composition, the correlation with liver metastasis, and expression of vascular endothelial growth factor (VEGF), matrix metalloprotei...
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| Veröffentlicht in: | Pancreas 2002-03, Vol.24 (2), p.169-178 |
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| creator | NAGAKAWA, Yuichi AOKI, Tatsuya KASUYA, Kazuhiko TSUCHIDA, Akihiko KOYANAGI, Yasuhisa |
| description | Pancreatic cancer frequently is associated with venous invasion and hematogenous metastasis.
To determine morphologic features of invaded veins, intratumoral vascular composition, the correlation with liver metastasis, and expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and MMP-9, and the mechanism of development of hematogenous metastasis.
We examined 32 patients with resected pancreatic cancer: 18 had postoperative liver metastasis, and 14 had no liver metastasis. Specimens were examined to determine the composition of veins and microvessels by staining of victoria-blue and CD34. We also investigated expression of VEGF, MMP-2, and MMP-9 by immunohistochemical staining.
Venous invasion was detected in 31 of 32 patients. Invaded venous densities of middle- and large-sized veins were significantly higher in patients with liver metastasis than in those with nonliver metastasis, and they were related to MMP-2 and MMP-9 overexpression. Invaded veins with fragmentation of the lumen through cancer cells were considered to be an intravasation of cancer (destroyed type vein), and their numbers were significantly related to liver metastasis, and MMP-2 and MMP-9 overexpression.
In conclusion, almost all the patients with pancreatic cancer showed venous invasion, indicating that invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion. |
| doi_str_mv | 10.1097/00006676-200203000-00008 |
| format | Article |
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To determine morphologic features of invaded veins, intratumoral vascular composition, the correlation with liver metastasis, and expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and MMP-9, and the mechanism of development of hematogenous metastasis.
We examined 32 patients with resected pancreatic cancer: 18 had postoperative liver metastasis, and 14 had no liver metastasis. Specimens were examined to determine the composition of veins and microvessels by staining of victoria-blue and CD34. We also investigated expression of VEGF, MMP-2, and MMP-9 by immunohistochemical staining.
Venous invasion was detected in 31 of 32 patients. Invaded venous densities of middle- and large-sized veins were significantly higher in patients with liver metastasis than in those with nonliver metastasis, and they were related to MMP-2 and MMP-9 overexpression. Invaded veins with fragmentation of the lumen through cancer cells were considered to be an intravasation of cancer (destroyed type vein), and their numbers were significantly related to liver metastasis, and MMP-2 and MMP-9 overexpression.
In conclusion, almost all the patients with pancreatic cancer showed venous invasion, indicating that invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-200203000-00008</identifier><identifier>PMID: 11854622</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma, Pancreatic Ductal - metabolism ; Carcinoma, Pancreatic Ductal - pathology ; Endothelial Growth Factors - analysis ; Endothelial Growth Factors - biosynthesis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver Neoplasms - metabolism ; Liver Neoplasms - secondary ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphokines - analysis ; Lymphokines - biosynthesis ; Male ; Matrix Metalloproteinase 2 - analysis ; Matrix Metalloproteinase 2 - biosynthesis ; Matrix Metalloproteinase 9 - analysis ; Matrix Metalloproteinase 9 - biosynthesis ; Medical sciences ; Microcirculation - pathology ; Middle Aged ; Neoplasm Invasiveness - pathology ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - pathology ; Tumors ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Veins - pathology</subject><ispartof>Pancreas, 2002-03, Vol.24 (2), p.169-178</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-6d18f96df4db6d9f27ab0ad8f601b9bac9277bc81dea2c4d0833156c528469243</citedby><cites>FETCH-LOGICAL-c370t-6d18f96df4db6d9f27ab0ad8f601b9bac9277bc81dea2c4d0833156c528469243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13508240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11854622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGAKAWA, Yuichi</creatorcontrib><creatorcontrib>AOKI, Tatsuya</creatorcontrib><creatorcontrib>KASUYA, Kazuhiko</creatorcontrib><creatorcontrib>TSUCHIDA, Akihiko</creatorcontrib><creatorcontrib>KOYANAGI, Yasuhisa</creatorcontrib><title>Histologic features of Venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>Pancreatic cancer frequently is associated with venous invasion and hematogenous metastasis.
To determine morphologic features of invaded veins, intratumoral vascular composition, the correlation with liver metastasis, and expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and MMP-9, and the mechanism of development of hematogenous metastasis.
We examined 32 patients with resected pancreatic cancer: 18 had postoperative liver metastasis, and 14 had no liver metastasis. Specimens were examined to determine the composition of veins and microvessels by staining of victoria-blue and CD34. We also investigated expression of VEGF, MMP-2, and MMP-9 by immunohistochemical staining.
Venous invasion was detected in 31 of 32 patients. Invaded venous densities of middle- and large-sized veins were significantly higher in patients with liver metastasis than in those with nonliver metastasis, and they were related to MMP-2 and MMP-9 overexpression. Invaded veins with fragmentation of the lumen through cancer cells were considered to be an intravasation of cancer (destroyed type vein), and their numbers were significantly related to liver metastasis, and MMP-2 and MMP-9 overexpression.
In conclusion, almost all the patients with pancreatic cancer showed venous invasion, indicating that invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Pancreatic Ductal - metabolism</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Endothelial Growth Factors - analysis</subject><subject>Endothelial Growth Factors - biosynthesis</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymphokines - analysis</subject><subject>Lymphokines - biosynthesis</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - analysis</subject><subject>Matrix Metalloproteinase 2 - biosynthesis</subject><subject>Matrix Metalloproteinase 9 - analysis</subject><subject>Matrix Metalloproteinase 9 - biosynthesis</subject><subject>Medical sciences</subject><subject>Microcirculation - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factors</subject><subject>Veins - pathology</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1TAQtRCIXgq_gLyBVQO2k9jOElWFIlViA2yjiR-tkRNfbKct38kPMbm90B2WLY_nnHl4DiGUs3ecDeo9wyWlko1gTLAWX83m0k_IjvetbDot9FOyY1r3TcuVOiEvSvnBGFdtPzwnJ5zrvpNC7Mjvy1Bqiuk6GOod1DW7QpOn392S1kLDcgslpOWMuvs9Qpu9weg1a4RM3WJTvXExQKTXOd3VG-rB1JQpLJbOUHO4p7OrEGPa51RdWKC4RvwfHs4OOCam2UWoW9W7gLljuHX5EFBwh61BuofFZGwdf2DQdPkleeYhFvfqeJ-Sbx8vvp5fNldfPn0-_3DVmFax2kjLtR-k9Z2dpB28UDAxsNpLxqdhAjMIpSajuXUgTGeZblveS9ML3clBdO0pefuQFzv_ubpSxzkU42KExeHwRsU7iYchUT8QTU6lZOfHfQ4z5F8jZ-Mm6PhX0PGfoAeXxtDXxxrrNDv7GHhUEAlvjgSUBKLPOIJQHnltz7TAHv4AtnevAg</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>NAGAKAWA, Yuichi</creator><creator>AOKI, Tatsuya</creator><creator>KASUYA, Kazuhiko</creator><creator>TSUCHIDA, Akihiko</creator><creator>KOYANAGI, Yasuhisa</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Histologic features of Venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer</title><author>NAGAKAWA, Yuichi ; AOKI, Tatsuya ; KASUYA, Kazuhiko ; TSUCHIDA, Akihiko ; KOYANAGI, Yasuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-6d18f96df4db6d9f27ab0ad8f601b9bac9277bc81dea2c4d0833156c528469243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Pancreatic Ductal - metabolism</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Endothelial Growth Factors - analysis</topic><topic>Endothelial Growth Factors - biosynthesis</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymphokines - analysis</topic><topic>Lymphokines - biosynthesis</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - analysis</topic><topic>Matrix Metalloproteinase 2 - biosynthesis</topic><topic>Matrix Metalloproteinase 9 - analysis</topic><topic>Matrix Metalloproteinase 9 - biosynthesis</topic><topic>Medical sciences</topic><topic>Microcirculation - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factors</topic><topic>Veins - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAGAKAWA, Yuichi</creatorcontrib><creatorcontrib>AOKI, Tatsuya</creatorcontrib><creatorcontrib>KASUYA, Kazuhiko</creatorcontrib><creatorcontrib>TSUCHIDA, Akihiko</creatorcontrib><creatorcontrib>KOYANAGI, Yasuhisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAGAKAWA, Yuichi</au><au>AOKI, Tatsuya</au><au>KASUYA, Kazuhiko</au><au>TSUCHIDA, Akihiko</au><au>KOYANAGI, Yasuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic features of Venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>24</volume><issue>2</issue><spage>169</spage><epage>178</epage><pages>169-178</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>Pancreatic cancer frequently is associated with venous invasion and hematogenous metastasis.
To determine morphologic features of invaded veins, intratumoral vascular composition, the correlation with liver metastasis, and expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and MMP-9, and the mechanism of development of hematogenous metastasis.
We examined 32 patients with resected pancreatic cancer: 18 had postoperative liver metastasis, and 14 had no liver metastasis. Specimens were examined to determine the composition of veins and microvessels by staining of victoria-blue and CD34. We also investigated expression of VEGF, MMP-2, and MMP-9 by immunohistochemical staining.
Venous invasion was detected in 31 of 32 patients. Invaded venous densities of middle- and large-sized veins were significantly higher in patients with liver metastasis than in those with nonliver metastasis, and they were related to MMP-2 and MMP-9 overexpression. Invaded veins with fragmentation of the lumen through cancer cells were considered to be an intravasation of cancer (destroyed type vein), and their numbers were significantly related to liver metastasis, and MMP-2 and MMP-9 overexpression.
In conclusion, almost all the patients with pancreatic cancer showed venous invasion, indicating that invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11854622</pmid><doi>10.1097/00006676-200203000-00008</doi><tpages>10</tpages></addata></record> |
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| ispartof | Pancreas, 2002-03, Vol.24 (2), p.169-178 |
| issn | 0885-3177 1536-4828 |
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| subjects | Adult Aged Biological and medical sciences Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Endothelial Growth Factors - analysis Endothelial Growth Factors - biosynthesis Female Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Neoplasms - metabolism Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphokines - analysis Lymphokines - biosynthesis Male Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - analysis Matrix Metalloproteinase 9 - biosynthesis Medical sciences Microcirculation - pathology Middle Aged Neoplasm Invasiveness - pathology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Tumors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Veins - pathology |
| title | Histologic features of Venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer |
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