Radiolytic Modification of Basic Amino Acid Residues in Peptides: Probes for Examining Protein−Protein Interactions

Protein footprinting utilizing hydroxyl radicals coupled with mass spectrometry has become a powerful technique for mapping the solvent accessible surface of proteins and examining protein−protein interactions in solution. Hydroxyl radicals generated by radiolysis or chemical methods efficiently rea...

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Veröffentlicht in:	Analytical chemistry (Washington) 2003-12, Vol.75 (24), p.6995-7007
Hauptverfasser:	Xu, Guozhong, Takamoto, Keiji, Chance, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - analysis Amino Acids - chemistry Amino Acids - radiation effects Aminoacids, peptides. Hormones. Neuropeptides Analytical chemistry Analytical, structural and metabolic biochemistry Arginine - analysis Arginine - chemistry Arginine - radiation effects Biological and medical sciences Carbon Dioxide - chemistry Chemical reactions Chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Gamma Rays Histidine - analysis Histidine - chemistry Histidine - radiation effects Lysine - analysis Lysine - chemistry Lysine - radiation effects Molecular Structure Oxidation-Reduction - radiation effects Peptides Peptides - analysis Peptides - chemistry Peptides - radiation effects Protein Binding Proteins Proteins - analysis Proteins - chemistry Proteins - radiation effects Radiochemical methods Radiology Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization - methods X-Rays
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