p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma
BACKGROUND p53 and Ki‐67 are regarded as potential interesting predictors of radioresistance, although their exact influence awaits confirmation on a large cohort of uniformly treated patients. METHODS In a retrospective cohort of 304 patients with squamous cell carcinoma of the head and neck who we...
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| Veröffentlicht in: | Cancer 2002-02, Vol.94 (3), p.713-722 |
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| creator | Couture, Christian Raybaud‐Diogène, Hélène Têtu, Bernard Bairati, Isabelle Murry, Danielle Allard, Josée Fortin, André |
| description | BACKGROUND
p53 and Ki‐67 are regarded as potential interesting predictors of radioresistance, although their exact influence awaits confirmation on a large cohort of uniformly treated patients.
METHODS
In a retrospective cohort of 304 patients with squamous cell carcinoma of the head and neck who were treated with radical radiotherapy, the expression levels of p53 and Ki‐67 were assessed by immunohistochemistry. Local control and survival curves were generated for p53 and Ki‐67 using the Kaplan–Meier method. The difference between curves was calculated in univariate and multivariate analyses.
RESULTS
The overexpression of p53 was associated with local treatment failure (P = 0.01) but not with survival (P = 0.09). In a Cox analysis, p53 overexpression remained an independent predictor of local failure, with a relative risk of local failure of 1.5 (P = 0.05). Low proliferation (Ki‐67 < 20%) was a significant factor in local failure for patients with tumors of the oral cavity only (P = 0.01). Patients with both unfavorable immunohistochemical markers (p53 overexpression and low proliferation) had a 45% rate of local control compared with a 67% rate for all other combinations (P = 0.002). This association was even more significant in patients with T1–T2 lesions (45% vs. 77%; P = 0.0002).
CONCLUSIONS
The results support the role of p53 as an independent predictor of local failure in patients with squamous cell carcinoma of the head and neck who are treated by radical radiotherapy, suggesting that it may predict radioresistance. Combined with p53, Ki‐67 may help in the better selection of patients for radiotherapy, especially for patients with early‐stage tumors. Prospective studies are now needed to confirm these results and to define better the role of these markers in the management of patients with head and neck carcinoma. Cancer 2002;94:713–22. © 2002 American Cancer Society.
DOI 10.1002/cncr.10232
In a retrospective study of patients who were treated uniformly with radical radiotherapy only, p53 overexpression determined by immunohistochemistry was associated strongly with local treatment failure, suggesting that it may predict radioresistance. Furthermore, p53 overexpression, when it was associated with low Ki‐67 expression, identified a subgroup of patients with an even worse response to radiotherapy. |
| doi_str_mv | 10.1002/cncr.10232 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71466763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71466763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4522-4efae778f9baedb0b1705f5814c29eefa6a09b33fab1d01db9920c522faa04093</originalsourceid><addsrcrecordid>eNqFkM1KxDAURoMoOo5ufADJRhdC9eanTbuUoo44KIiCu3KbJhin047JDOLOR_AZfRIzzoA7Xd1ccu73wSHkgMEpA-BnutM-vrjgG2TAoFAJMMk3yQAA8iSV4mmH7IbwElfFU7FNdhjLUyVADsholgqKXUNv3NfHZ6YoBjpFPzE-0N5Sj43rvQkuzLHThrqOPhtsfi46oydUo9eu66e4R7YstsHsr-eQPF5ePJSjZHx3dV2ejxMtU84TaSwapXJb1GiaGmqmILVpzqTmhYmfGUJRC2GxZg2wpi4KDjpeWkSQUIghOV7lznz_ujBhXk1d0KZtsTP9IlSKySxTmfgXZLnMJFPLxJMVqH0fgje2mnkXHbxXDKql4GopuPoRHOHDdeqinprmF10bjcDRGsCgsbU-enPhlxOxlUsVObbi3lxr3v-orMrb8n5V_g3E5pH9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18464179</pqid></control><display><type>article</type><title>p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Couture, Christian ; Raybaud‐Diogène, Hélène ; Têtu, Bernard ; Bairati, Isabelle ; Murry, Danielle ; Allard, Josée ; Fortin, André</creator><creatorcontrib>Couture, Christian ; Raybaud‐Diogène, Hélène ; Têtu, Bernard ; Bairati, Isabelle ; Murry, Danielle ; Allard, Josée ; Fortin, André</creatorcontrib><description>BACKGROUND
p53 and Ki‐67 are regarded as potential interesting predictors of radioresistance, although their exact influence awaits confirmation on a large cohort of uniformly treated patients.
METHODS
In a retrospective cohort of 304 patients with squamous cell carcinoma of the head and neck who were treated with radical radiotherapy, the expression levels of p53 and Ki‐67 were assessed by immunohistochemistry. Local control and survival curves were generated for p53 and Ki‐67 using the Kaplan–Meier method. The difference between curves was calculated in univariate and multivariate analyses.
RESULTS
The overexpression of p53 was associated with local treatment failure (P = 0.01) but not with survival (P = 0.09). In a Cox analysis, p53 overexpression remained an independent predictor of local failure, with a relative risk of local failure of 1.5 (P = 0.05). Low proliferation (Ki‐67 < 20%) was a significant factor in local failure for patients with tumors of the oral cavity only (P = 0.01). Patients with both unfavorable immunohistochemical markers (p53 overexpression and low proliferation) had a 45% rate of local control compared with a 67% rate for all other combinations (P = 0.002). This association was even more significant in patients with T1–T2 lesions (45% vs. 77%; P = 0.0002).
CONCLUSIONS
The results support the role of p53 as an independent predictor of local failure in patients with squamous cell carcinoma of the head and neck who are treated by radical radiotherapy, suggesting that it may predict radioresistance. Combined with p53, Ki‐67 may help in the better selection of patients for radiotherapy, especially for patients with early‐stage tumors. Prospective studies are now needed to confirm these results and to define better the role of these markers in the management of patients with head and neck carcinoma. Cancer 2002;94:713–22. © 2002 American Cancer Society.
DOI 10.1002/cncr.10232
In a retrospective study of patients who were treated uniformly with radical radiotherapy only, p53 overexpression determined by immunohistochemistry was associated strongly with local treatment failure, suggesting that it may predict radioresistance. Furthermore, p53 overexpression, when it was associated with low Ki‐67 expression, identified a subgroup of patients with an even worse response to radiotherapy.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.10232</identifier><identifier>PMID: 11857304</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Cohort Studies ; Diseases of the upper aerodigestive tract ; Ent and stomatology ; Female ; Gene Expression Regulation, Neoplastic ; head and neck carcinoma ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - radiotherapy ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Ki-67 Antigen - biosynthesis ; Ki‐67 ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; p53 ; Predictive Value of Tests ; prognosis ; radioresistance ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Retrospective Studies ; Survival Analysis ; Tumor Suppressor Protein p53 - analysis ; Tumor Suppressor Protein p53 - biosynthesis</subject><ispartof>Cancer, 2002-02, Vol.94 (3), p.713-722</ispartof><rights>Copyright © 2002 American Cancer Society</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 American Cancer Society. DOI 10.1002/cncr.10232</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4522-4efae778f9baedb0b1705f5814c29eefa6a09b33fab1d01db9920c522faa04093</citedby><cites>FETCH-LOGICAL-c4522-4efae778f9baedb0b1705f5814c29eefa6a09b33fab1d01db9920c522faa04093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.10232$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.10232$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13464247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11857304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Couture, Christian</creatorcontrib><creatorcontrib>Raybaud‐Diogène, Hélène</creatorcontrib><creatorcontrib>Têtu, Bernard</creatorcontrib><creatorcontrib>Bairati, Isabelle</creatorcontrib><creatorcontrib>Murry, Danielle</creatorcontrib><creatorcontrib>Allard, Josée</creatorcontrib><creatorcontrib>Fortin, André</creatorcontrib><title>p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
p53 and Ki‐67 are regarded as potential interesting predictors of radioresistance, although their exact influence awaits confirmation on a large cohort of uniformly treated patients.
METHODS
In a retrospective cohort of 304 patients with squamous cell carcinoma of the head and neck who were treated with radical radiotherapy, the expression levels of p53 and Ki‐67 were assessed by immunohistochemistry. Local control and survival curves were generated for p53 and Ki‐67 using the Kaplan–Meier method. The difference between curves was calculated in univariate and multivariate analyses.
RESULTS
The overexpression of p53 was associated with local treatment failure (P = 0.01) but not with survival (P = 0.09). In a Cox analysis, p53 overexpression remained an independent predictor of local failure, with a relative risk of local failure of 1.5 (P = 0.05). Low proliferation (Ki‐67 < 20%) was a significant factor in local failure for patients with tumors of the oral cavity only (P = 0.01). Patients with both unfavorable immunohistochemical markers (p53 overexpression and low proliferation) had a 45% rate of local control compared with a 67% rate for all other combinations (P = 0.002). This association was even more significant in patients with T1–T2 lesions (45% vs. 77%; P = 0.0002).
CONCLUSIONS
The results support the role of p53 as an independent predictor of local failure in patients with squamous cell carcinoma of the head and neck who are treated by radical radiotherapy, suggesting that it may predict radioresistance. Combined with p53, Ki‐67 may help in the better selection of patients for radiotherapy, especially for patients with early‐stage tumors. Prospective studies are now needed to confirm these results and to define better the role of these markers in the management of patients with head and neck carcinoma. Cancer 2002;94:713–22. © 2002 American Cancer Society.
DOI 10.1002/cncr.10232
In a retrospective study of patients who were treated uniformly with radical radiotherapy only, p53 overexpression determined by immunohistochemistry was associated strongly with local treatment failure, suggesting that it may predict radioresistance. Furthermore, p53 overexpression, when it was associated with low Ki‐67 expression, identified a subgroup of patients with an even worse response to radiotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Cohort Studies</subject><subject>Diseases of the upper aerodigestive tract</subject><subject>Ent and stomatology</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>head and neck carcinoma</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Ki-67 Antigen - biosynthesis</subject><subject>Ki‐67</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>p53</subject><subject>Predictive Value of Tests</subject><subject>prognosis</subject><subject>radioresistance</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KxDAURoMoOo5ufADJRhdC9eanTbuUoo44KIiCu3KbJhin047JDOLOR_AZfRIzzoA7Xd1ccu73wSHkgMEpA-BnutM-vrjgG2TAoFAJMMk3yQAA8iSV4mmH7IbwElfFU7FNdhjLUyVADsholgqKXUNv3NfHZ6YoBjpFPzE-0N5Sj43rvQkuzLHThrqOPhtsfi46oydUo9eu66e4R7YstsHsr-eQPF5ePJSjZHx3dV2ejxMtU84TaSwapXJb1GiaGmqmILVpzqTmhYmfGUJRC2GxZg2wpi4KDjpeWkSQUIghOV7lznz_ujBhXk1d0KZtsTP9IlSKySxTmfgXZLnMJFPLxJMVqH0fgje2mnkXHbxXDKql4GopuPoRHOHDdeqinprmF10bjcDRGsCgsbU-enPhlxOxlUsVObbi3lxr3v-orMrb8n5V_g3E5pH9</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Couture, Christian</creator><creator>Raybaud‐Diogène, Hélène</creator><creator>Têtu, Bernard</creator><creator>Bairati, Isabelle</creator><creator>Murry, Danielle</creator><creator>Allard, Josée</creator><creator>Fortin, André</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma</title><author>Couture, Christian ; Raybaud‐Diogène, Hélène ; Têtu, Bernard ; Bairati, Isabelle ; Murry, Danielle ; Allard, Josée ; Fortin, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4522-4efae778f9baedb0b1705f5814c29eefa6a09b33fab1d01db9920c522faa04093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Cohort Studies</topic><topic>Diseases of the upper aerodigestive tract</topic><topic>Ent and stomatology</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>head and neck carcinoma</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Ki-67 Antigen - biosynthesis</topic><topic>Ki‐67</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>p53</topic><topic>Predictive Value of Tests</topic><topic>prognosis</topic><topic>radioresistance</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Couture, Christian</creatorcontrib><creatorcontrib>Raybaud‐Diogène, Hélène</creatorcontrib><creatorcontrib>Têtu, Bernard</creatorcontrib><creatorcontrib>Bairati, Isabelle</creatorcontrib><creatorcontrib>Murry, Danielle</creatorcontrib><creatorcontrib>Allard, Josée</creatorcontrib><creatorcontrib>Fortin, André</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Couture, Christian</au><au>Raybaud‐Diogène, Hélène</au><au>Têtu, Bernard</au><au>Bairati, Isabelle</au><au>Murry, Danielle</au><au>Allard, Josée</au><au>Fortin, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>94</volume><issue>3</issue><spage>713</spage><epage>722</epage><pages>713-722</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
p53 and Ki‐67 are regarded as potential interesting predictors of radioresistance, although their exact influence awaits confirmation on a large cohort of uniformly treated patients.
METHODS
In a retrospective cohort of 304 patients with squamous cell carcinoma of the head and neck who were treated with radical radiotherapy, the expression levels of p53 and Ki‐67 were assessed by immunohistochemistry. Local control and survival curves were generated for p53 and Ki‐67 using the Kaplan–Meier method. The difference between curves was calculated in univariate and multivariate analyses.
RESULTS
The overexpression of p53 was associated with local treatment failure (P = 0.01) but not with survival (P = 0.09). In a Cox analysis, p53 overexpression remained an independent predictor of local failure, with a relative risk of local failure of 1.5 (P = 0.05). Low proliferation (Ki‐67 < 20%) was a significant factor in local failure for patients with tumors of the oral cavity only (P = 0.01). Patients with both unfavorable immunohistochemical markers (p53 overexpression and low proliferation) had a 45% rate of local control compared with a 67% rate for all other combinations (P = 0.002). This association was even more significant in patients with T1–T2 lesions (45% vs. 77%; P = 0.0002).
CONCLUSIONS
The results support the role of p53 as an independent predictor of local failure in patients with squamous cell carcinoma of the head and neck who are treated by radical radiotherapy, suggesting that it may predict radioresistance. Combined with p53, Ki‐67 may help in the better selection of patients for radiotherapy, especially for patients with early‐stage tumors. Prospective studies are now needed to confirm these results and to define better the role of these markers in the management of patients with head and neck carcinoma. Cancer 2002;94:713–22. © 2002 American Cancer Society.
DOI 10.1002/cncr.10232
In a retrospective study of patients who were treated uniformly with radical radiotherapy only, p53 overexpression determined by immunohistochemistry was associated strongly with local treatment failure, suggesting that it may predict radioresistance. Furthermore, p53 overexpression, when it was associated with low Ki‐67 expression, identified a subgroup of patients with an even worse response to radiotherapy.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11857304</pmid><doi>10.1002/cncr.10232</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Cohort Studies Diseases of the upper aerodigestive tract Ent and stomatology Female Gene Expression Regulation, Neoplastic head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Humans Immunohistochemistry Ki-67 Antigen - analysis Ki-67 Antigen - biosynthesis Ki‐67 Male Medical sciences Middle Aged Neoplasm Recurrence, Local p53 Predictive Value of Tests prognosis radioresistance Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Retrospective Studies Survival Analysis Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - biosynthesis |
| title | p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma |
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