Efficient Sialyltransferase Inhibitors Based on Glycosides of N-Acetylglucosamine

d-Glucosamine was transformed into phenyl and 2-benzoyloxyethyl N-acetylglucosamine β-glycosides 6a and 6b, respectively. Transformation of 6a,b into 6-O-unprotected N-acetylglucosamine derivatives 9a,b permitted the generation of an aldehyde group in the 6-position. Treatment of these intermediates...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-02, Vol.124 (8), p.1632-1637
Hauptverfasser:	Schwörer, Ralf, Schmidt, Richard R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - analogs & derivatives Acetylglucosamine - chemical synthesis Acetylglucosamine - pharmacology Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Exact sciences and technology Glycosides - chemical synthesis Glycosides - pharmacology Organic chemistry Preparations and properties Sialyltransferases - antagonists & inhibitors
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