Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm

We have isolated a novel secreted dorsalizing factor of the neural tube, Xenopus Tiarin, which belongs to the olfactomedin-related family. Tiarin expression starts at the late gastrula stage in the nonneural ectoderm adjacent to the anterior neural plate. Overexpression of Tiarin in the embryo cause...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-02, Vol.33 (4), p.515-528
Hauptverfasser:	Tsuda, Hiroshi, Sasai, Noriaki, Matsuo-Takasaki, Mami, Sakuragi, Makoto, Murakami, Yoshinobu, Sasai, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning - physiology Cell Differentiation - physiology Cell division Central Nervous System - embryology Central Nervous System - metabolism Cloning Ectoderm - cytology Ectoderm - metabolism Embryo, Nonmammalian Embryonic Induction - physiology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Eye - drug effects Eye - embryology Eye - metabolism Female Freshwater Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Genes Glycoproteins - genetics Glycoproteins - metabolism Growth Substances - metabolism Head - embryology Head - physiology Hybridization Mesoderm - cytology Mesoderm - drug effects Mesoderm - metabolism Molecular Sequence Data Neural Crest - drug effects Neural Crest - embryology Neural Crest - metabolism Regulation RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Messenger - pharmacology Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Signal Transduction - physiology Transcription factors Xenopus laevis - embryology Xenopus laevis - metabolism Xenopus Proteins - metabolism
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