Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm
We have isolated a novel secreted dorsalizing factor of the neural tube, Xenopus Tiarin, which belongs to the olfactomedin-related family. Tiarin expression starts at the late gastrula stage in the nonneural ectoderm adjacent to the anterior neural plate. Overexpression of Tiarin in the embryo cause...
Gespeichert in:
| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2002-02, Vol.33 (4), p.515-528 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 528 |
|---|---|
| container_issue | 4 |
| container_start_page | 515 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 33 |
| creator | Tsuda, Hiroshi Sasai, Noriaki Matsuo-Takasaki, Mami Sakuragi, Makoto Murakami, Yoshinobu Sasai, Yoshiki |
| description | We have isolated a novel secreted dorsalizing factor of the neural tube,
Xenopus Tiarin, which belongs to the olfactomedin-related family.
Tiarin expression starts at the late gastrula stage in the nonneural ectoderm adjacent to the anterior neural plate. Overexpression of Tiarin in the embryo causes expansion of dorsal neural markers and suppression of ventral markers. In the eye-forming field, Tiarin overexpression induces the retinal markers and represses optic stalk markers. Tiarin directly dorsalizes neural tissues in the absence of mesodermal tissues and antagonizes the ventralizing activity of Sonic hedghog (Shh). Unlike BMP4, another dorsalizing factor, Tiarin does not display antineuralizing activity on the ectoderm or mesoderm-ventralizing activity. These findings show that Tiarin is a novel patterning signal candidate acting in the specification of the dorsal neural tube. |
| doi_str_mv | 10.1016/S0896-6273(02)00590-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71465876</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0896627302005901</els_id><sourcerecordid>71465876</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-2d3f42af34320e9f06ba96952ccaf2559cdb7168964beb0b5342ee9f4c7fcd6b3</originalsourceid><addsrcrecordid>eNqFkV1rFDEUhoNY7Fr9CUpAEAVH8zHJTK5EatcWyip0Be9CJnNGU2eTbZIp1At_u5nuYqE3vcpFnvdJznkRekHJe0qo_HBBWiUryRr-hrC3hAhFKvoILShRTVVTpR6jxX_kED1N6ZIQWgtFn6BDSlshBWsW6O_nEJMZ3R-TXfA4DDj_AryCKZoRr6cOcHeDf4AP2ynhtTPR-XfY4FW4hhF_MzlD9M7_xEtjc4j4AmyEDP2cmkXL0fjf8_0qeL-TnoLp8Umhe4ibZ-hgMGOC5_vzCH1fnqyPT6vzr1_Ojj-dV1ZwnivW86FmZuA1ZwTUQGRnlFSCWWsGJoSyfddQWcatO-hIJ3jNoHC1bQbby44fodc77zaGqwlS1huXLIzlexCmpBtaS9E28kGQtrxthWgL-OoeeBmm6MsQmgrCG0kYn3ViR9kYUoow6G10GxNvNCV67lHf9qjnkjRh-rZHTUvu5d4-dRvo71L74grwcQdA2dq1g6iTdeAt9C6CzboP7oEn_gHKn60M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503760236</pqid></control><display><type>article</type><title>Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Tsuda, Hiroshi ; Sasai, Noriaki ; Matsuo-Takasaki, Mami ; Sakuragi, Makoto ; Murakami, Yoshinobu ; Sasai, Yoshiki</creator><creatorcontrib>Tsuda, Hiroshi ; Sasai, Noriaki ; Matsuo-Takasaki, Mami ; Sakuragi, Makoto ; Murakami, Yoshinobu ; Sasai, Yoshiki</creatorcontrib><description>We have isolated a novel secreted dorsalizing factor of the neural tube,
Xenopus Tiarin, which belongs to the olfactomedin-related family.
Tiarin expression starts at the late gastrula stage in the nonneural ectoderm adjacent to the anterior neural plate. Overexpression of Tiarin in the embryo causes expansion of dorsal neural markers and suppression of ventral markers. In the eye-forming field, Tiarin overexpression induces the retinal markers and represses optic stalk markers. Tiarin directly dorsalizes neural tissues in the absence of mesodermal tissues and antagonizes the ventralizing activity of Sonic hedghog (Shh). Unlike BMP4, another dorsalizing factor, Tiarin does not display antineuralizing activity on the ectoderm or mesoderm-ventralizing activity. These findings show that Tiarin is a novel patterning signal candidate acting in the specification of the dorsal neural tube.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(02)00590-1</identifier><identifier>PMID: 11856527</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Body Patterning - physiology ; Cell Differentiation - physiology ; Cell division ; Central Nervous System - embryology ; Central Nervous System - metabolism ; Cloning ; Ectoderm - cytology ; Ectoderm - metabolism ; Embryo, Nonmammalian ; Embryonic Induction - physiology ; Extracellular Matrix Proteins - genetics ; Extracellular Matrix Proteins - metabolism ; Eye - drug effects ; Eye - embryology ; Eye - metabolism ; Female ; Freshwater ; Gene Expression Regulation, Developmental - drug effects ; Gene Expression Regulation, Developmental - physiology ; Genes ; Glycoproteins - genetics ; Glycoproteins - metabolism ; Growth Substances - metabolism ; Head - embryology ; Head - physiology ; Hybridization ; Mesoderm - cytology ; Mesoderm - drug effects ; Mesoderm - metabolism ; Molecular Sequence Data ; Neural Crest - drug effects ; Neural Crest - embryology ; Neural Crest - metabolism ; Regulation ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA, Messenger - pharmacology ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Signal Transduction - physiology ; Transcription factors ; Xenopus laevis - embryology ; Xenopus laevis - metabolism ; Xenopus Proteins - metabolism</subject><ispartof>Neuron (Cambridge, Mass.), 2002-02, Vol.33 (4), p.515-528</ispartof><rights>2002 Cell Press</rights><rights>Copyright Elsevier Limited Feb 14, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-2d3f42af34320e9f06ba96952ccaf2559cdb7168964beb0b5342ee9f4c7fcd6b3</citedby><cites>FETCH-LOGICAL-c533t-2d3f42af34320e9f06ba96952ccaf2559cdb7168964beb0b5342ee9f4c7fcd6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0896-6273(02)00590-1$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11856527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuda, Hiroshi</creatorcontrib><creatorcontrib>Sasai, Noriaki</creatorcontrib><creatorcontrib>Matsuo-Takasaki, Mami</creatorcontrib><creatorcontrib>Sakuragi, Makoto</creatorcontrib><creatorcontrib>Murakami, Yoshinobu</creatorcontrib><creatorcontrib>Sasai, Yoshiki</creatorcontrib><title>Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>We have isolated a novel secreted dorsalizing factor of the neural tube,
Xenopus Tiarin, which belongs to the olfactomedin-related family.
Tiarin expression starts at the late gastrula stage in the nonneural ectoderm adjacent to the anterior neural plate. Overexpression of Tiarin in the embryo causes expansion of dorsal neural markers and suppression of ventral markers. In the eye-forming field, Tiarin overexpression induces the retinal markers and represses optic stalk markers. Tiarin directly dorsalizes neural tissues in the absence of mesodermal tissues and antagonizes the ventralizing activity of Sonic hedghog (Shh). Unlike BMP4, another dorsalizing factor, Tiarin does not display antineuralizing activity on the ectoderm or mesoderm-ventralizing activity. These findings show that Tiarin is a novel patterning signal candidate acting in the specification of the dorsal neural tube.</description><subject>Animals</subject><subject>Body Patterning - physiology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell division</subject><subject>Central Nervous System - embryology</subject><subject>Central Nervous System - metabolism</subject><subject>Cloning</subject><subject>Ectoderm - cytology</subject><subject>Ectoderm - metabolism</subject><subject>Embryo, Nonmammalian</subject><subject>Embryonic Induction - physiology</subject><subject>Extracellular Matrix Proteins - genetics</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Eye - drug effects</subject><subject>Eye - embryology</subject><subject>Eye - metabolism</subject><subject>Female</subject><subject>Freshwater</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Genes</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - metabolism</subject><subject>Growth Substances - metabolism</subject><subject>Head - embryology</subject><subject>Head - physiology</subject><subject>Hybridization</subject><subject>Mesoderm - cytology</subject><subject>Mesoderm - drug effects</subject><subject>Mesoderm - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Neural Crest - drug effects</subject><subject>Neural Crest - embryology</subject><subject>Neural Crest - metabolism</subject><subject>Regulation</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Messenger - pharmacology</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Signal Transduction - physiology</subject><subject>Transcription factors</subject><subject>Xenopus laevis - embryology</subject><subject>Xenopus laevis - metabolism</subject><subject>Xenopus Proteins - metabolism</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoNY7Fr9CUpAEAVH8zHJTK5EatcWyip0Be9CJnNGU2eTbZIp1At_u5nuYqE3vcpFnvdJznkRekHJe0qo_HBBWiUryRr-hrC3hAhFKvoILShRTVVTpR6jxX_kED1N6ZIQWgtFn6BDSlshBWsW6O_nEJMZ3R-TXfA4DDj_AryCKZoRr6cOcHeDf4AP2ynhtTPR-XfY4FW4hhF_MzlD9M7_xEtjc4j4AmyEDP2cmkXL0fjf8_0qeL-TnoLp8Umhe4ibZ-hgMGOC5_vzCH1fnqyPT6vzr1_Ojj-dV1ZwnivW86FmZuA1ZwTUQGRnlFSCWWsGJoSyfddQWcatO-hIJ3jNoHC1bQbby44fodc77zaGqwlS1huXLIzlexCmpBtaS9E28kGQtrxthWgL-OoeeBmm6MsQmgrCG0kYn3ViR9kYUoow6G10GxNvNCV67lHf9qjnkjRh-rZHTUvu5d4-dRvo71L74grwcQdA2dq1g6iTdeAt9C6CzboP7oEn_gHKn60M</recordid><startdate>20020214</startdate><enddate>20020214</enddate><creator>Tsuda, Hiroshi</creator><creator>Sasai, Noriaki</creator><creator>Matsuo-Takasaki, Mami</creator><creator>Sakuragi, Makoto</creator><creator>Murakami, Yoshinobu</creator><creator>Sasai, Yoshiki</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20020214</creationdate><title>Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm</title><author>Tsuda, Hiroshi ; Sasai, Noriaki ; Matsuo-Takasaki, Mami ; Sakuragi, Makoto ; Murakami, Yoshinobu ; Sasai, Yoshiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-2d3f42af34320e9f06ba96952ccaf2559cdb7168964beb0b5342ee9f4c7fcd6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Body Patterning - physiology</topic><topic>Cell Differentiation - physiology</topic><topic>Cell division</topic><topic>Central Nervous System - embryology</topic><topic>Central Nervous System - metabolism</topic><topic>Cloning</topic><topic>Ectoderm - cytology</topic><topic>Ectoderm - metabolism</topic><topic>Embryo, Nonmammalian</topic><topic>Embryonic Induction - physiology</topic><topic>Extracellular Matrix Proteins - genetics</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Eye - drug effects</topic><topic>Eye - embryology</topic><topic>Eye - metabolism</topic><topic>Female</topic><topic>Freshwater</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Genes</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - metabolism</topic><topic>Growth Substances - metabolism</topic><topic>Head - embryology</topic><topic>Head - physiology</topic><topic>Hybridization</topic><topic>Mesoderm - cytology</topic><topic>Mesoderm - drug effects</topic><topic>Mesoderm - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Neural Crest - drug effects</topic><topic>Neural Crest - embryology</topic><topic>Neural Crest - metabolism</topic><topic>Regulation</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Messenger - pharmacology</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Signal Transduction - physiology</topic><topic>Transcription factors</topic><topic>Xenopus laevis - embryology</topic><topic>Xenopus laevis - metabolism</topic><topic>Xenopus Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuda, Hiroshi</creatorcontrib><creatorcontrib>Sasai, Noriaki</creatorcontrib><creatorcontrib>Matsuo-Takasaki, Mami</creatorcontrib><creatorcontrib>Sakuragi, Makoto</creatorcontrib><creatorcontrib>Murakami, Yoshinobu</creatorcontrib><creatorcontrib>Sasai, Yoshiki</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuda, Hiroshi</au><au>Sasai, Noriaki</au><au>Matsuo-Takasaki, Mami</au><au>Sakuragi, Makoto</au><au>Murakami, Yoshinobu</au><au>Sasai, Yoshiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2002-02-14</date><risdate>2002</risdate><volume>33</volume><issue>4</issue><spage>515</spage><epage>528</epage><pages>515-528</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>We have isolated a novel secreted dorsalizing factor of the neural tube,
Xenopus Tiarin, which belongs to the olfactomedin-related family.
Tiarin expression starts at the late gastrula stage in the nonneural ectoderm adjacent to the anterior neural plate. Overexpression of Tiarin in the embryo causes expansion of dorsal neural markers and suppression of ventral markers. In the eye-forming field, Tiarin overexpression induces the retinal markers and represses optic stalk markers. Tiarin directly dorsalizes neural tissues in the absence of mesodermal tissues and antagonizes the ventralizing activity of Sonic hedghog (Shh). Unlike BMP4, another dorsalizing factor, Tiarin does not display antineuralizing activity on the ectoderm or mesoderm-ventralizing activity. These findings show that Tiarin is a novel patterning signal candidate acting in the specification of the dorsal neural tube.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11856527</pmid><doi>10.1016/S0896-6273(02)00590-1</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 2002-02, Vol.33 (4), p.515-528 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71465876 |
| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Body Patterning - physiology Cell Differentiation - physiology Cell division Central Nervous System - embryology Central Nervous System - metabolism Cloning Ectoderm - cytology Ectoderm - metabolism Embryo, Nonmammalian Embryonic Induction - physiology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Eye - drug effects Eye - embryology Eye - metabolism Female Freshwater Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Genes Glycoproteins - genetics Glycoproteins - metabolism Growth Substances - metabolism Head - embryology Head - physiology Hybridization Mesoderm - cytology Mesoderm - drug effects Mesoderm - metabolism Molecular Sequence Data Neural Crest - drug effects Neural Crest - embryology Neural Crest - metabolism Regulation RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Messenger - pharmacology Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Signal Transduction - physiology Transcription factors Xenopus laevis - embryology Xenopus laevis - metabolism Xenopus Proteins - metabolism |
| title | Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T17%3A53%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dorsalization%20of%20the%20Neural%20Tube%20by%20Xenopus%20Tiarin,%20a%20Novel%20Patterning%20Factor%20Secreted%20by%20the%20Flanking%20Nonneural%20Head%20Ectoderm&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Tsuda,%20Hiroshi&rft.date=2002-02-14&rft.volume=33&rft.issue=4&rft.spage=515&rft.epage=528&rft.pages=515-528&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/S0896-6273(02)00590-1&rft_dat=%3Cproquest_cross%3E71465876%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1503760236&rft_id=info:pmid/11856527&rft_els_id=S0896627302005901&rfr_iscdi=true |