Dose‐related effects of motilin on proximal gastrointestinal motility
Aim: To assess non‐invasively the dose–response relations for the effects of exogenous motilin on antrum contraction frequency, gall‐bladder volume and gastric myoelectrical activity. Methods: In a double‐blind, randomized, placebo‐controlled, five‐way crossover study, 10 fasted healthy volunteers w...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2002-01, Vol.16 (1), p.129-135 |
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| creator | Kamerling, I. M. C. Van Haarst, A. D. Burggraaf, J. Schoemaker, H. C. Biemond, I. Jones, R. Cohen, A. F. Masclee, A. A. M. |
| description | Aim:
To assess non‐invasively the dose–response relations for the effects of exogenous motilin on antrum contraction frequency, gall‐bladder volume and gastric myoelectrical activity.
Methods:
In a double‐blind, randomized, placebo‐controlled, five‐way crossover study, 10 fasted healthy volunteers were infused intravenously with synthetic human motilin (0.5, 1, 2 and 4 pmol.min/kg) or placebo for 60 min. Gall‐bladder volume and antrum contractions were assessed by ultrasonography and gastric myoelectrical activity by electrogastrography. Motilin concentrations were measured using a radioimmunoassay.
Results:
Baseline plasma motilin levels (60 pmol/L) were similar for all treatments. Motilin levels increased upon the start of infusion and rapidly returned to baseline after cessation of the infusion. At motilin doses of 2 and 4 pmol.min/kg, the antrum contraction frequency was significantly augmented, with maximum differences of two contractions per 2‐min interval compared to placebo, while no changes in gastric myoelectrical activity were observed. Changes in gall‐bladder volume were not significantly different for any of the motilin doses compared to placebo.
Conclusions:
Motilin increased antrum contraction frequency, whereas no effect on gastric myoelectrical activity was observed. Antrum contraction frequency appears to be a useful biomarker for motilin efficacy, and motilin doses of 2 and 4 pmol.min/kg were equally effective. |
| doi_str_mv | 10.1046/j.1365-2036.2002.01142.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71465581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71465581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4452-169d6c4d1e49c80bef740b4f03c4332b770c34b6d8c3c1f0524fc2d137d941c13</originalsourceid><addsrcrecordid>eNqNkL9OwzAQhy0EoqXwCigLbAnnP3GSgaEqUJAqwVBmK3Fs5MpNip2KduMReEaehIREdGXyyf7u7ucPoQBDhIHxm1WEKY9DApRHBIBEgDEj0e4Ijf8ejtEYCM9CkmI6QmferwCAJ0BO0QjjNOaQJmM0v6u9-v78csrmjSoDpbWSjQ9qHazrxlhTBXUVbFy9M-vcBm-5b1xtqkb5xlTtRQ81-3N0onPr1cVwTtDrw_1y9hgunudPs-kilIzFJMQ8K7lkJVYskykUSicMCqaBSkYpKZIEJGUFL1NJJdYQE6YlKTFNyoxhiekEXfdz20jv2zaFWBsvlbV5peqtFwlmPI7TDkx7ULrae6e02Lj2C24vMIhOoliJzpXoXIlOoviVKHZt6-WwY1usVXloHKy1wNUA5F7mVru8ksYfOMpJxjJoudue-zBW7f8dQExfll1FfwCRto39</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71465581</pqid></control><display><type>article</type><title>Dose‐related effects of motilin on proximal gastrointestinal motility</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Kamerling, I. M. C. ; Van Haarst, A. D. ; Burggraaf, J. ; Schoemaker, H. C. ; Biemond, I. ; Jones, R. ; Cohen, A. F. ; Masclee, A. A. M.</creator><creatorcontrib>Kamerling, I. M. C. ; Van Haarst, A. D. ; Burggraaf, J. ; Schoemaker, H. C. ; Biemond, I. ; Jones, R. ; Cohen, A. F. ; Masclee, A. A. M.</creatorcontrib><description>Aim:
To assess non‐invasively the dose–response relations for the effects of exogenous motilin on antrum contraction frequency, gall‐bladder volume and gastric myoelectrical activity.
Methods:
In a double‐blind, randomized, placebo‐controlled, five‐way crossover study, 10 fasted healthy volunteers were infused intravenously with synthetic human motilin (0.5, 1, 2 and 4 pmol.min/kg) or placebo for 60 min. Gall‐bladder volume and antrum contractions were assessed by ultrasonography and gastric myoelectrical activity by electrogastrography. Motilin concentrations were measured using a radioimmunoassay.
Results:
Baseline plasma motilin levels (60 pmol/L) were similar for all treatments. Motilin levels increased upon the start of infusion and rapidly returned to baseline after cessation of the infusion. At motilin doses of 2 and 4 pmol.min/kg, the antrum contraction frequency was significantly augmented, with maximum differences of two contractions per 2‐min interval compared to placebo, while no changes in gastric myoelectrical activity were observed. Changes in gall‐bladder volume were not significantly different for any of the motilin doses compared to placebo.
Conclusions:
Motilin increased antrum contraction frequency, whereas no effect on gastric myoelectrical activity was observed. Antrum contraction frequency appears to be a useful biomarker for motilin efficacy, and motilin doses of 2 and 4 pmol.min/kg were equally effective.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1046/j.1365-2036.2002.01142.x</identifier><identifier>PMID: 11856087</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cross-Over Studies ; Digestive system ; Dose-Response Relationship, Drug ; Double-Blind Method ; Electrophysiology ; Female ; Gallbladder - anatomy & histology ; Gallbladder - drug effects ; Gastrointestinal Agents - pharmacology ; Gastrointestinal Motility - drug effects ; Humans ; Male ; Medical sciences ; Motilin - pharmacology ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Pharmacology. Drug treatments ; Pyloric Antrum - drug effects ; Pyloric Antrum - physiology</subject><ispartof>Alimentary pharmacology & therapeutics, 2002-01, Vol.16 (1), p.129-135</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4452-169d6c4d1e49c80bef740b4f03c4332b770c34b6d8c3c1f0524fc2d137d941c13</citedby><cites>FETCH-LOGICAL-c4452-169d6c4d1e49c80bef740b4f03c4332b770c34b6d8c3c1f0524fc2d137d941c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2036.2002.01142.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2036.2002.01142.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13629490$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11856087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamerling, I. M. C.</creatorcontrib><creatorcontrib>Van Haarst, A. D.</creatorcontrib><creatorcontrib>Burggraaf, J.</creatorcontrib><creatorcontrib>Schoemaker, H. C.</creatorcontrib><creatorcontrib>Biemond, I.</creatorcontrib><creatorcontrib>Jones, R.</creatorcontrib><creatorcontrib>Cohen, A. F.</creatorcontrib><creatorcontrib>Masclee, A. A. M.</creatorcontrib><title>Dose‐related effects of motilin on proximal gastrointestinal motility</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Aim:
To assess non‐invasively the dose–response relations for the effects of exogenous motilin on antrum contraction frequency, gall‐bladder volume and gastric myoelectrical activity.
Methods:
In a double‐blind, randomized, placebo‐controlled, five‐way crossover study, 10 fasted healthy volunteers were infused intravenously with synthetic human motilin (0.5, 1, 2 and 4 pmol.min/kg) or placebo for 60 min. Gall‐bladder volume and antrum contractions were assessed by ultrasonography and gastric myoelectrical activity by electrogastrography. Motilin concentrations were measured using a radioimmunoassay.
Results:
Baseline plasma motilin levels (60 pmol/L) were similar for all treatments. Motilin levels increased upon the start of infusion and rapidly returned to baseline after cessation of the infusion. At motilin doses of 2 and 4 pmol.min/kg, the antrum contraction frequency was significantly augmented, with maximum differences of two contractions per 2‐min interval compared to placebo, while no changes in gastric myoelectrical activity were observed. Changes in gall‐bladder volume were not significantly different for any of the motilin doses compared to placebo.
Conclusions:
Motilin increased antrum contraction frequency, whereas no effect on gastric myoelectrical activity was observed. Antrum contraction frequency appears to be a useful biomarker for motilin efficacy, and motilin doses of 2 and 4 pmol.min/kg were equally effective.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross-Over Studies</subject><subject>Digestive system</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Gallbladder - anatomy & histology</subject><subject>Gallbladder - drug effects</subject><subject>Gastrointestinal Agents - pharmacology</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motilin - pharmacology</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyloric Antrum - drug effects</subject><subject>Pyloric Antrum - physiology</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL9OwzAQhy0EoqXwCigLbAnnP3GSgaEqUJAqwVBmK3Fs5MpNip2KduMReEaehIREdGXyyf7u7ucPoQBDhIHxm1WEKY9DApRHBIBEgDEj0e4Ijf8ejtEYCM9CkmI6QmferwCAJ0BO0QjjNOaQJmM0v6u9-v78csrmjSoDpbWSjQ9qHazrxlhTBXUVbFy9M-vcBm-5b1xtqkb5xlTtRQ81-3N0onPr1cVwTtDrw_1y9hgunudPs-kilIzFJMQ8K7lkJVYskykUSicMCqaBSkYpKZIEJGUFL1NJJdYQE6YlKTFNyoxhiekEXfdz20jv2zaFWBsvlbV5peqtFwlmPI7TDkx7ULrae6e02Lj2C24vMIhOoliJzpXoXIlOoviVKHZt6-WwY1usVXloHKy1wNUA5F7mVru8ksYfOMpJxjJoudue-zBW7f8dQExfll1FfwCRto39</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Kamerling, I. M. C.</creator><creator>Van Haarst, A. D.</creator><creator>Burggraaf, J.</creator><creator>Schoemaker, H. C.</creator><creator>Biemond, I.</creator><creator>Jones, R.</creator><creator>Cohen, A. F.</creator><creator>Masclee, A. A. M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Dose‐related effects of motilin on proximal gastrointestinal motility</title><author>Kamerling, I. M. C. ; Van Haarst, A. D. ; Burggraaf, J. ; Schoemaker, H. C. ; Biemond, I. ; Jones, R. ; Cohen, A. F. ; Masclee, A. A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4452-169d6c4d1e49c80bef740b4f03c4332b770c34b6d8c3c1f0524fc2d137d941c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross-Over Studies</topic><topic>Digestive system</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Gallbladder - anatomy & histology</topic><topic>Gallbladder - drug effects</topic><topic>Gastrointestinal Agents - pharmacology</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motilin - pharmacology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyloric Antrum - drug effects</topic><topic>Pyloric Antrum - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamerling, I. M. C.</creatorcontrib><creatorcontrib>Van Haarst, A. D.</creatorcontrib><creatorcontrib>Burggraaf, J.</creatorcontrib><creatorcontrib>Schoemaker, H. C.</creatorcontrib><creatorcontrib>Biemond, I.</creatorcontrib><creatorcontrib>Jones, R.</creatorcontrib><creatorcontrib>Cohen, A. F.</creatorcontrib><creatorcontrib>Masclee, A. A. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamerling, I. M. C.</au><au>Van Haarst, A. D.</au><au>Burggraaf, J.</au><au>Schoemaker, H. C.</au><au>Biemond, I.</au><au>Jones, R.</au><au>Cohen, A. F.</au><au>Masclee, A. A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose‐related effects of motilin on proximal gastrointestinal motility</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2002-01</date><risdate>2002</risdate><volume>16</volume><issue>1</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Aim:
To assess non‐invasively the dose–response relations for the effects of exogenous motilin on antrum contraction frequency, gall‐bladder volume and gastric myoelectrical activity.
Methods:
In a double‐blind, randomized, placebo‐controlled, five‐way crossover study, 10 fasted healthy volunteers were infused intravenously with synthetic human motilin (0.5, 1, 2 and 4 pmol.min/kg) or placebo for 60 min. Gall‐bladder volume and antrum contractions were assessed by ultrasonography and gastric myoelectrical activity by electrogastrography. Motilin concentrations were measured using a radioimmunoassay.
Results:
Baseline plasma motilin levels (60 pmol/L) were similar for all treatments. Motilin levels increased upon the start of infusion and rapidly returned to baseline after cessation of the infusion. At motilin doses of 2 and 4 pmol.min/kg, the antrum contraction frequency was significantly augmented, with maximum differences of two contractions per 2‐min interval compared to placebo, while no changes in gastric myoelectrical activity were observed. Changes in gall‐bladder volume were not significantly different for any of the motilin doses compared to placebo.
Conclusions:
Motilin increased antrum contraction frequency, whereas no effect on gastric myoelectrical activity was observed. Antrum contraction frequency appears to be a useful biomarker for motilin efficacy, and motilin doses of 2 and 4 pmol.min/kg were equally effective.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11856087</pmid><doi>10.1046/j.1365-2036.2002.01142.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alimentary pharmacology & therapeutics, 2002-01, Vol.16 (1), p.129-135 |
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| source | Wiley Free Content; MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Biological and medical sciences Cross-Over Studies Digestive system Dose-Response Relationship, Drug Double-Blind Method Electrophysiology Female Gallbladder - anatomy & histology Gallbladder - drug effects Gastrointestinal Agents - pharmacology Gastrointestinal Motility - drug effects Humans Male Medical sciences Motilin - pharmacology Muscle, Smooth - drug effects Muscle, Smooth - physiology Pharmacology. Drug treatments Pyloric Antrum - drug effects Pyloric Antrum - physiology |
| title | Dose‐related effects of motilin on proximal gastrointestinal motility |
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