Securin and B-cyclin/CDK are the only essential targets of the APC

The anaphase-promoting complex/cyclosome (APC) is a highly conserved ubiquitin ligase that controls passage through the cell cycle by targeting many proteins for proteolysis. The complex is composed of at least thirteen core subunits, eight of which are essential, and two activating subunits, Cdc20...

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Veröffentlicht in:	Nature cell biology 2003-12, Vol.5 (12), p.1090-1094
Hauptverfasser:	Toczyski, David P, Thornton, Brian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase-Promoting Complex-Cyclosome Biological research Biomedical and Life Sciences Cancer Research Cell Biology Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell division Cyclin B - metabolism Cyclin B1 Cyclin-Dependent Kinase Inhibitor Proteins Cyclin-Dependent Kinases - metabolism Cyclins Cytochemistry Developmental Biology Feedback, Physiological - physiology letter Life Sciences Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Protein Subunits - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Securin Stem Cells Ubiquitin-proteasome system Ubiquitin-Protein Ligase Complexes - genetics Ubiquitin-Protein Ligase Complexes - metabolism
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