Merkel cell carcinoma and HIV infection
Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity. To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309 365 individua...
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| Veröffentlicht in: | The Lancet (British edition) 2002-02, Vol.359 (9305), p.497-498 |
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| container_issue | 9305 |
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| creator | Engels, Eric A Frisch, Morten Goedert, James J Biggar, Robert J Miller, Robert W |
| description | Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity. To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309 365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We identified six cases of MCC, corresponding to a relative risk of 13·4 (95% CI 4·9–29·1) compared with the general population. These results suggest that immune suppression induced by the human immunodeficiency virus increases MCC risk. |
| doi_str_mv | 10.1016/S0140-6736(02)07668-7 |
| format | Article |
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To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309 365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We identified six cases of MCC, corresponding to a relative risk of 13·4 (95% CI 4·9–29·1) compared with the general population. 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These results suggest that immune suppression induced by the human immunodeficiency virus increases MCC risk.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - epidemiology</subject><subject>Adult</subject><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Merkel Cell - complications</subject><subject>Carcinoma, Merkel Cell - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sarcoma</subject><subject>SEER Program</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - complications</subject><subject>Skin Neoplasms - epidemiology</subject><subject>United States - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309 365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We identified six cases of MCC, corresponding to a relative risk of 13·4 (95% CI 4·9–29·1) compared with the general population. These results suggest that immune suppression induced by the human immunodeficiency virus increases MCC risk.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>11853800</pmid><doi>10.1016/S0140-6736(02)07668-7</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2002-02, Vol.359 (9305), p.497-498 |
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| language | eng |
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| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - epidemiology Adult AIDS Biological and medical sciences Carcinoma, Merkel Cell - complications Carcinoma, Merkel Cell - epidemiology Epidemiology Female HIV Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Male Medical sciences Middle Aged Risk Factors Sarcoma SEER Program Skin cancer Skin Neoplasms - complications Skin Neoplasms - epidemiology United States - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Merkel cell carcinoma and HIV infection |
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