A retrospective study of clozapine and electroencephalographic abnormalities in schizophrenic patients
This study investigated the incidence and nature of clozapine-associated electroencephalographic (EEG) abnormalities and the relationship between EEG abnormality and clozapine dosage in Korean schizophrenic patients. Fifty schizophrenic patients with normal baseline EEG and with additional EEG recor...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2002, Vol.26 (1), p.139-144 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Chung, Sun-Ju Jeong, Seong-Hoon Ahn, Yong-Min Kang, Ung-Gu Koo, Young-Jin Ha, Jee-Hyun Lee, Sang-Gun Kim, Yong-Sik |
| description | This study investigated the incidence and nature of clozapine-associated electroencephalographic (EEG) abnormalities and the relationship between EEG abnormality and clozapine dosage in Korean schizophrenic patients. Fifty schizophrenic patients with normal baseline EEG and with additional EEG record examined during clozapine treatment more than once were included. Thirty-one patients (62%) showed abnormal EEGs after clozapine treatment, and two of them had seizures. The majority of EEG abnormalities presented as nonspecific slow waves (SW). Spikes (or spike and wave complexes; SP) and frontal intermittent rhythmic delta activity (FIRDA) were relatively rarely observed. The probability of EEG abnormality was linearly dependent on the daily dose of clozapine and patient's age. Our results can be summarized as follows: (1) a substantial proportion of Korean patients treated with clozapine develops EEG abnormalities, and its incidence is comparable to the published results in Caucasian patients; (2) EEG abnormalities occurred in a dose-dependent manner; and (3) the occurrence of EEG abnormalities did not necessarily lead to future seizure development, except in a small number of cases. |
| doi_str_mv | 10.1016/S0278-5846(01)00238-X |
| format | Article |
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Fifty schizophrenic patients with normal baseline EEG and with additional EEG record examined during clozapine treatment more than once were included. Thirty-one patients (62%) showed abnormal EEGs after clozapine treatment, and two of them had seizures. The majority of EEG abnormalities presented as nonspecific slow waves (SW). Spikes (or spike and wave complexes; SP) and frontal intermittent rhythmic delta activity (FIRDA) were relatively rarely observed. The probability of EEG abnormality was linearly dependent on the daily dose of clozapine and patient's age. Our results can be summarized as follows: (1) a substantial proportion of Korean patients treated with clozapine develops EEG abnormalities, and its incidence is comparable to the published results in Caucasian patients; (2) EEG abnormalities occurred in a dose-dependent manner; and (3) the occurrence of EEG abnormalities did not necessarily lead to future seizure development, except in a small number of cases.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/S0278-5846(01)00238-X</identifier><identifier>PMID: 11853104</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Clozapine ; Clozapine - therapeutic use ; Drug toxicity and drugs side effects treatment ; Electroencephalography ; Electroencephalography - drug effects ; Female ; Humans ; Koreans ; Male ; Medical sciences ; Pharmacology. 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Fifty schizophrenic patients with normal baseline EEG and with additional EEG record examined during clozapine treatment more than once were included. Thirty-one patients (62%) showed abnormal EEGs after clozapine treatment, and two of them had seizures. The majority of EEG abnormalities presented as nonspecific slow waves (SW). Spikes (or spike and wave complexes; SP) and frontal intermittent rhythmic delta activity (FIRDA) were relatively rarely observed. The probability of EEG abnormality was linearly dependent on the daily dose of clozapine and patient's age. Our results can be summarized as follows: (1) a substantial proportion of Korean patients treated with clozapine develops EEG abnormalities, and its incidence is comparable to the published results in Caucasian patients; (2) EEG abnormalities occurred in a dose-dependent manner; and (3) the occurrence of EEG abnormalities did not necessarily lead to future seizure development, except in a small number of cases.</description><subject>Adult</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clozapine</subject><subject>Clozapine - therapeutic use</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electroencephalography</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Koreans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - physiopathology</subject><subject>Seizure</subject><subject>Toxicity: nervous system and muscle</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi1ERUPgJ4B8AcFhy8za-3WqqoovqVIPgNSb5bXHxGhjL_amUvvr6zQRPXKy9M4zY_sZxt4gnCFg--kH1F1fNb1sPwB-BKhFX908YyvsSyxrbJ-z1T_klL3M-Q8AoADxgp0i9o1AkCvmLniiJcU8k1n8LfG87Owdj46bKd7r2QfiOlhOU6mnSMHQvNFT_J30vPGG6zHEtNWTXzxl7gPPZuPv47xJFEp51iUPS37FTpyeMr0-nmv268vnn5ffqqvrr98vL64qI5tuqcbBdYMcyXRAWvRoRommH0YhbAdWYmedlEgIFqRuYShh7Uho5wj1AFqs2fvD3DnFvzvKi9r6bGiadKC4y6pD2UrZNgVsDqApf8-JnJqT3-p0pxDUXrB6FKz29hSgehSsbkrf2-MFu3FL9qnraLQA746AzkZPLulgfH7iRFPLpmxhzc4PHBUdt56Sysbv9Vqfimplo__PUx4AhZGauQ</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Chung, Sun-Ju</creator><creator>Jeong, Seong-Hoon</creator><creator>Ahn, Yong-Min</creator><creator>Kang, Ung-Gu</creator><creator>Koo, Young-Jin</creator><creator>Ha, Jee-Hyun</creator><creator>Lee, Sang-Gun</creator><creator>Kim, Yong-Sik</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>A retrospective study of clozapine and electroencephalographic abnormalities in schizophrenic patients</title><author>Chung, Sun-Ju ; Jeong, Seong-Hoon ; Ahn, Yong-Min ; Kang, Ung-Gu ; Koo, Young-Jin ; Ha, Jee-Hyun ; Lee, Sang-Gun ; Kim, Yong-Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-b9f794bec70ea381cb41c89b33d70d417df441e10d04a60970d2fe3affe1a90a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clozapine</topic><topic>Clozapine - therapeutic use</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electroencephalography</topic><topic>Electroencephalography - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Koreans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - physiopathology</topic><topic>Seizure</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Sun-Ju</creatorcontrib><creatorcontrib>Jeong, Seong-Hoon</creatorcontrib><creatorcontrib>Ahn, Yong-Min</creatorcontrib><creatorcontrib>Kang, Ung-Gu</creatorcontrib><creatorcontrib>Koo, Young-Jin</creatorcontrib><creatorcontrib>Ha, Jee-Hyun</creatorcontrib><creatorcontrib>Lee, Sang-Gun</creatorcontrib><creatorcontrib>Kim, Yong-Sik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Sun-Ju</au><au>Jeong, Seong-Hoon</au><au>Ahn, Yong-Min</au><au>Kang, Ung-Gu</au><au>Koo, Young-Jin</au><au>Ha, Jee-Hyun</au><au>Lee, Sang-Gun</au><au>Kim, Yong-Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective study of clozapine and electroencephalographic abnormalities in schizophrenic patients</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2002</date><risdate>2002</risdate><volume>26</volume><issue>1</issue><spage>139</spage><epage>144</epage><pages>139-144</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>This study investigated the incidence and nature of clozapine-associated electroencephalographic (EEG) abnormalities and the relationship between EEG abnormality and clozapine dosage in Korean schizophrenic patients. Fifty schizophrenic patients with normal baseline EEG and with additional EEG record examined during clozapine treatment more than once were included. Thirty-one patients (62%) showed abnormal EEGs after clozapine treatment, and two of them had seizures. The majority of EEG abnormalities presented as nonspecific slow waves (SW). Spikes (or spike and wave complexes; SP) and frontal intermittent rhythmic delta activity (FIRDA) were relatively rarely observed. The probability of EEG abnormality was linearly dependent on the daily dose of clozapine and patient's age. Our results can be summarized as follows: (1) a substantial proportion of Korean patients treated with clozapine develops EEG abnormalities, and its incidence is comparable to the published results in Caucasian patients; (2) EEG abnormalities occurred in a dose-dependent manner; and (3) the occurrence of EEG abnormalities did not necessarily lead to future seizure development, except in a small number of cases.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>11853104</pmid><doi>10.1016/S0278-5846(01)00238-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Antipsychotic Agents - therapeutic use Biological and medical sciences Clozapine Clozapine - therapeutic use Drug toxicity and drugs side effects treatment Electroencephalography Electroencephalography - drug effects Female Humans Koreans Male Medical sciences Pharmacology. Drug treatments Retrospective Studies Schizophrenia Schizophrenia - drug therapy Schizophrenia - physiopathology Seizure Toxicity: nervous system and muscle |
| title | A retrospective study of clozapine and electroencephalographic abnormalities in schizophrenic patients |
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