Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic bcl-2-family proteins

Epidemiological data and in vitro studies on cancer chemoprevention by tea polyphenols have gained attention recently from the scientific community, nutritionists, the pharmaceutical industry, and the public. Despite the several efforts made recently to elucidate the molecular basis for the anticanc...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (23), p.8118-8121
Hauptverfasser:	LEONE, Marilisa, DAYONG ZHAI, SARETH, Sina, KITADA, Shinichi, REED, John C, PELLECCHIA, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anticarcinogenic Agents - chemistry Anticarcinogenic Agents - metabolism Anticarcinogenic Agents - pharmacology Antineoplastic agents Biflavonoids - chemistry Biflavonoids - metabolism Biflavonoids - pharmacology Binding Sites Binding, Competitive Biological and medical sciences Camellia sinensis - chemistry Catechin - chemistry Catechin - metabolism Catechin - pharmacology Flavonoids - chemistry Flavonoids - metabolism Flavonoids - pharmacology Gallic Acid - analogs & derivatives Gallic Acid - chemistry Gallic Acid - metabolism Gallic Acid - pharmacology Medical sciences Models, Molecular Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Pharmacology. Drug treatments Phenols - chemistry Phenols - metabolism Phenols - pharmacology Polyphenols Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - metabolism Tea Tumors
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