Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy

Graves’ disease (GD) is a very common autoimmune disorder of the thyroid in which stimulatory antibodies bind to the thyrotropin receptor and activate glandular function, resulting in hyperthyroidism. In addition, some patients with GD develop localized manifestations including ophthalmopathy (GO) a...

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Veröffentlicht in:	Endocrine reviews 2003-12, Vol.24 (6), p.802-835
Hauptverfasser:	Prabhakar, Bellur S, Bahn, Rebecca S, Smith, Terry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation analysis Animal models Antibodies Autoantigens Autoantigens - immunology Autoimmune diseases Autoimmunity Biological and medical sciences Cell activation Chemokines Cloning Connective Tissue - immunology Connective tissues Endocrinopathies Environment Environmental factors Eye diseases Fibroblasts Genetic analysis Genetic factors Glycosaminoglycans - metabolism Graves disease Graves Disease - etiology Graves Disease - genetics Graves Disease - immunology Graves Disease - physiopathology Humans Hyperthyroidism Immunoglobulins Lymphocytes Lymphocytes B Medical sciences Molecular modelling Molecular structure Muscles Non tumoral diseases. Target tissue resistance. Benign neoplasms Ocular muscles Orbit - immunology Orbit - pathology Pathogenesis Receptors Receptors, Thyrotropin - immunology Risk Factors Structure-function relationships Thyroid Thyroid Gland - immunology Thyroid-stimulating hormone Thyroid. Thyroid axis (diseases)
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