Cellular prion protein: on the road for functions
Cellular prion (PrPc) is a plasma membrane glycosyphosphatidylinositol-anchored protein present in neurons but also in other cell types. Protein conservation among species suggests that PrPc may have important physiological roles. Cellular and molecular approaches have established several novel feat...
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| Veröffentlicht in: | FEBS Letters 2002-02, Vol.512 (1), p.25-28 |
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| container_title | FEBS Letters |
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| creator | Martins, Vilma R Linden, Rafael Prado, Marco A.M Walz, Roger Sakamoto, Américo C Izquierdo, Ivan Brentani, Ricardo R |
| description | Cellular prion (PrPc) is a plasma membrane glycosyphosphatidylinositol-anchored protein present in neurons but also in other cell types. Protein conservation among species suggests that PrPc may have important physiological roles. Cellular and molecular approaches have established several novel features of the regulation of PrPc expression, cellular trafficking as well as its participation in copper uptake, protection against oxidative stress, cell adhesion, differentiation, signaling and cell survival. It is therefore likely that PrPc plays pleiotropic roles in neuronal and non-neuronal cells, and as such the loss of function of PrPc may be an important component of various diseases. |
| doi_str_mv | 10.1016/S0014-5793(02)02291-3 |
| format | Article |
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Protein conservation among species suggests that PrPc may have important physiological roles. Cellular and molecular approaches have established several novel features of the regulation of PrPc expression, cellular trafficking as well as its participation in copper uptake, protection against oxidative stress, cell adhesion, differentiation, signaling and cell survival. 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| source | MEDLINE; Wiley Free Content; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Cellular prion protein Gene regulation GFP, green fluorescent protein GPI, glycosyphosphatidylinositol Human diseases Laminin Models, Biological Nervous System Diseases - etiology Neurons - physiology NGF, nerve growth factor p66, putative PrPc membrane ligand Prn-p, gene that codes for the cellular prion protein Programmed cell death PrPC Proteins - physiology PrPc, cellular prion protein PrPsc, prion scrapie, infectious protein Trafficking |
| title | Cellular prion protein: on the road for functions |
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