Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors

ADP-ribosylation is involved in nuclear factor κB (NF-κB)-dependent gene expression induced by lipopolysaccharide in murine macrophages. Here we have investigated the mechanism by which ADP-ribosylation inhibitors block signaling pathways induced in macrophages. In RAW264.7 macrophages the inducers...

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Veröffentlicht in:	Biological chemistry 2003-10, Vol.384 (10-11), p.1509-1513
Hauptverfasser:	Page, C. Le, Wietzerbin, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Iodobenzylguanidine - pharmacology Adenosine Diphosphate Ribose - metabolism ADP-Ribosylation Factors - antagonists & inhibitors Animals Antioxidants - pharmacology Benzamides - pharmacology Cell Line Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Inflammation - chemically induced Interleukin-1 - analysis Lipopolysaccharides - analysis Macrophages - drug effects Macrophages - metabolism Mice Mitogen-Activated Protein Kinases - analysis Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism NF-kappa B - biosynthesis NF-kappa B - chemistry NF-kappa B - genetics Niacinamide - pharmacology p38 Mitogen-Activated Protein Kinases Phosphorylation - drug effects Proline - analogs & derivatives Proline - pharmacology Protein Kinases - metabolism Reactive Oxygen Species - analysis Signal Transduction - drug effects Thiocarbamates - pharmacology Tumor Necrosis Factor-alpha - analysis
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