NKT Cell Frequency in Japanese Type 1 Diabetes

NKT Cell Frequency in Japanese Type 1 Diabetes

: A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet‐associated Ab...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2003-11, Vol.1005 (1), p.230-232
Hauptverfasser: OIKAWA, YOICHI, SHIMADA, AKIRA, YAMADA, SATORU, MOTOHASHI, YOSHIKO, NAKAGAWA, YOSHINORI, IRIE, JUN-ICHIRO, MARUYAMA, TARO, SARUTA, TAKAO
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Diabetes Mellitus, Type 1 - immunology
Female
Glycated Hemoglobin A - analysis
Humans
Japan
Killer Cells, Natural - immunology
Male
Middle Aged
NKT cell
type 1 diabetes
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Zusammenfassung:: A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet‐associated Ab+ and Ab− Japanese “classic” type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab−“classic” type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1288.033