Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities
Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts. We assessed the relation between usual nutrient intakes and age-related cortical and PSC lens opacities. We studied 492 nondiabetic w...
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| Veröffentlicht in: | The American journal of clinical nutrition 2002-03, Vol.75 (3), p.540-549 |
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| creator | TAYLOR, Allen JACQUES, Paul F WILLETT, Walter C CHYLACK, Leo T HANKINSON, Susan E KHU, Patricia M ROGERS, Gail FRIEND, Judith TUNG, William WOLFE, John K PADHYE, Nita |
| description | Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts.
We assessed the relation between usual nutrient intakes and age-related cortical and PSC lens opacities.
We studied 492 nondiabetic women aged 53-73 y from the Nurses' Health Study cohort who were without previously diagnosed cataracts. Usual nutrient intake was calculated as the average intake from 5 food-frequency questionnaires collected over a 13-15-y period before the eye examination. Duration of vitamin supplement use was determined from 7 questionnaires collected during this same period. We defined cortical opacities as grade > or = 0.5 and subcapsular opacities as grade > or =0.3 of the Lens Opacities Classification System III.
Some lenses had more than one opacity. No nutrient measure was related to prevalence of opacities in the full sample, but significant interactions were seen between age and vitamin C intake (P = 0.02) for odds of cortical opacities and between smoking status and folate (P = 0.02), alpha-carotene (P = 0.02), beta-carotene (P = 0.005), and total carotenoids (P = 0.02) for odds of PSC opacities. For women aged or = 362 mg/d was associated with a 57% lower odds ratio (0.43; 95% CI: 0.2, 0.93) of developing a cortical cataract than was an intake or = 10 y was associated with a 60% lower odds ratio (0.40; 0.18, 0.87) than was no vitamin C supplement use. Prevalence of PSC opacities was related to total carotenoid intake in women who never smoked (P = 0.02).
Our results support a role for vitamin C in diminishing the risk of cortical cataracts in women aged |
| doi_str_mv | 10.1093/ajcn/75.3.540 |
| format | Article |
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We assessed the relation between usual nutrient intakes and age-related cortical and PSC lens opacities.
We studied 492 nondiabetic women aged 53-73 y from the Nurses' Health Study cohort who were without previously diagnosed cataracts. Usual nutrient intake was calculated as the average intake from 5 food-frequency questionnaires collected over a 13-15-y period before the eye examination. Duration of vitamin supplement use was determined from 7 questionnaires collected during this same period. We defined cortical opacities as grade > or = 0.5 and subcapsular opacities as grade > or =0.3 of the Lens Opacities Classification System III.
Some lenses had more than one opacity. No nutrient measure was related to prevalence of opacities in the full sample, but significant interactions were seen between age and vitamin C intake (P = 0.02) for odds of cortical opacities and between smoking status and folate (P = 0.02), alpha-carotene (P = 0.02), beta-carotene (P = 0.005), and total carotenoids (P = 0.02) for odds of PSC opacities. For women aged <60 y, a vitamin C intake > or = 362 mg/d was associated with a 57% lower odds ratio (0.43; 95% CI: 0.2, 0.93) of developing a cortical cataract than was an intake <140 mg/d, and use of vitamin C supplements for > or = 10 y was associated with a 60% lower odds ratio (0.40; 0.18, 0.87) than was no vitamin C supplement use. Prevalence of PSC opacities was related to total carotenoid intake in women who never smoked (P = 0.02).
Our results support a role for vitamin C in diminishing the risk of cortical cataracts in women aged <60 y and for carotenoids in diminishing the risk of PSC cataracts in women who have never smoked.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/75.3.540</identifier><identifier>PMID: 11864861</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Age Factors ; Aged ; Aging - drug effects ; Antioxidants - administration & dosage ; Antioxidants - analysis ; Ascorbic Acid - administration & dosage ; Biological and medical sciences ; Carotenoids - administration & dosage ; Carotenoids - blood ; Cataract - epidemiology ; Cataract - etiology ; Cataract - prevention & control ; Cataracts ; Cohort Studies ; Diet Surveys ; Dietary Supplements ; Female ; Humans ; Lens diseases ; Lens Nucleus, Crystalline - drug effects ; Longitudinal Studies ; Medical sciences ; Middle Aged ; Nutrition ; Nutrition Assessment ; Odds Ratio ; Ophthalmology ; Prevalence ; Prospective Studies ; Smoking ; Surveys and Questionnaires ; United States - epidemiology ; Vitamins ; Vitamins - administration & dosage ; Vitamins - blood ; Women ; Women's Health</subject><ispartof>The American journal of clinical nutrition, 2002-03, Vol.75 (3), p.540-549</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Mar 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-761513cd3d0af64e90cc5441d94d07511bb1319ab7205518b4bc15f67e9bb29c3</citedby><cites>FETCH-LOGICAL-c453t-761513cd3d0af64e90cc5441d94d07511bb1319ab7205518b4bc15f67e9bb29c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13506811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11864861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAYLOR, Allen</creatorcontrib><creatorcontrib>JACQUES, Paul F</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><creatorcontrib>CHYLACK, Leo T</creatorcontrib><creatorcontrib>HANKINSON, Susan E</creatorcontrib><creatorcontrib>KHU, Patricia M</creatorcontrib><creatorcontrib>ROGERS, Gail</creatorcontrib><creatorcontrib>FRIEND, Judith</creatorcontrib><creatorcontrib>TUNG, William</creatorcontrib><creatorcontrib>WOLFE, John K</creatorcontrib><creatorcontrib>PADHYE, Nita</creatorcontrib><title>Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts.
We assessed the relation between usual nutrient intakes and age-related cortical and PSC lens opacities.
We studied 492 nondiabetic women aged 53-73 y from the Nurses' Health Study cohort who were without previously diagnosed cataracts. Usual nutrient intake was calculated as the average intake from 5 food-frequency questionnaires collected over a 13-15-y period before the eye examination. Duration of vitamin supplement use was determined from 7 questionnaires collected during this same period. We defined cortical opacities as grade > or = 0.5 and subcapsular opacities as grade > or =0.3 of the Lens Opacities Classification System III.
Some lenses had more than one opacity. No nutrient measure was related to prevalence of opacities in the full sample, but significant interactions were seen between age and vitamin C intake (P = 0.02) for odds of cortical opacities and between smoking status and folate (P = 0.02), alpha-carotene (P = 0.02), beta-carotene (P = 0.005), and total carotenoids (P = 0.02) for odds of PSC opacities. For women aged <60 y, a vitamin C intake > or = 362 mg/d was associated with a 57% lower odds ratio (0.43; 95% CI: 0.2, 0.93) of developing a cortical cataract than was an intake <140 mg/d, and use of vitamin C supplements for > or = 10 y was associated with a 60% lower odds ratio (0.40; 0.18, 0.87) than was no vitamin C supplement use. Prevalence of PSC opacities was related to total carotenoid intake in women who never smoked (P = 0.02).
Our results support a role for vitamin C in diminishing the risk of cortical cataracts in women aged <60 y and for carotenoids in diminishing the risk of PSC cataracts in women who have never smoked.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aging - drug effects</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - analysis</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - administration & dosage</subject><subject>Carotenoids - blood</subject><subject>Cataract - epidemiology</subject><subject>Cataract - etiology</subject><subject>Cataract - prevention & control</subject><subject>Cataracts</subject><subject>Cohort Studies</subject><subject>Diet Surveys</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Humans</subject><subject>Lens diseases</subject><subject>Lens Nucleus, Crystalline - drug effects</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Odds Ratio</subject><subject>Ophthalmology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Smoking</subject><subject>Surveys and Questionnaires</subject><subject>United States - epidemiology</subject><subject>Vitamins</subject><subject>Vitamins - administration & dosage</subject><subject>Vitamins - blood</subject><subject>Women</subject><subject>Women's Health</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0UFr3DAQBWBRUppN2mOvxQSamzcaS7LsYwhtEljIpT2LkSwHbW3JleRCoD--2u5CICeN4OMxzCPkM9At0J7d4N74Gym2bCs4fUc20LOuZg2VZ2RDKW3qHlpxTi5S2lMKDe_aD-QcoGvLBBvydxf8c51tnCvnM_6yVRirPy7j7Hyq0A-VwRiy9cENx38YylCQxTi9VPhs62gnzLbIELMzOP1nS0gl1YVYpVUbXNI6YawmW1LDgsZlZ9NH8n7EKdlPp_eS_Pz-7cfdQ717un-8u93VhguWa9mCAGYGNlAcW257aozgHIaeD1QKAK2BQY9aNlQI6DTXBsTYSttr3fSGXZLrY-4Sw-_Vpqxml4ydJvQ2rElJ4G0jpSzw6g3chzX6sptq2OGywKGg-ohMDClFO6oluhnjiwKqDp2oQydKCsVU6aT4L6fQVc92eNWnEgr4egKYyvnGiN649OqYoG0HwP4BUQyVyg</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>TAYLOR, Allen</creator><creator>JACQUES, Paul F</creator><creator>WILLETT, Walter C</creator><creator>CHYLACK, Leo T</creator><creator>HANKINSON, Susan E</creator><creator>KHU, Patricia M</creator><creator>ROGERS, Gail</creator><creator>FRIEND, Judith</creator><creator>TUNG, William</creator><creator>WOLFE, John K</creator><creator>PADHYE, Nita</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities</title><author>TAYLOR, Allen ; JACQUES, Paul F ; WILLETT, Walter C ; CHYLACK, Leo T ; HANKINSON, Susan E ; KHU, Patricia M ; ROGERS, Gail ; FRIEND, Judith ; TUNG, William ; WOLFE, John K ; PADHYE, Nita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-761513cd3d0af64e90cc5441d94d07511bb1319ab7205518b4bc15f67e9bb29c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aging - drug effects</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - analysis</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - administration & dosage</topic><topic>Carotenoids - blood</topic><topic>Cataract - epidemiology</topic><topic>Cataract - etiology</topic><topic>Cataract - prevention & control</topic><topic>Cataracts</topic><topic>Cohort Studies</topic><topic>Diet Surveys</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Humans</topic><topic>Lens diseases</topic><topic>Lens Nucleus, Crystalline - drug effects</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Odds Ratio</topic><topic>Ophthalmology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Smoking</topic><topic>Surveys and Questionnaires</topic><topic>United States - epidemiology</topic><topic>Vitamins</topic><topic>Vitamins - administration & dosage</topic><topic>Vitamins - blood</topic><topic>Women</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAYLOR, Allen</creatorcontrib><creatorcontrib>JACQUES, Paul F</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><creatorcontrib>CHYLACK, Leo T</creatorcontrib><creatorcontrib>HANKINSON, Susan E</creatorcontrib><creatorcontrib>KHU, Patricia M</creatorcontrib><creatorcontrib>ROGERS, Gail</creatorcontrib><creatorcontrib>FRIEND, Judith</creatorcontrib><creatorcontrib>TUNG, William</creatorcontrib><creatorcontrib>WOLFE, John K</creatorcontrib><creatorcontrib>PADHYE, Nita</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAYLOR, Allen</au><au>JACQUES, Paul F</au><au>WILLETT, Walter C</au><au>CHYLACK, Leo T</au><au>HANKINSON, Susan E</au><au>KHU, Patricia M</au><au>ROGERS, Gail</au><au>FRIEND, Judith</au><au>TUNG, William</au><au>WOLFE, John K</au><au>PADHYE, Nita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>75</volume><issue>3</issue><spage>540</spage><epage>549</epage><pages>540-549</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts.
We assessed the relation between usual nutrient intakes and age-related cortical and PSC lens opacities.
We studied 492 nondiabetic women aged 53-73 y from the Nurses' Health Study cohort who were without previously diagnosed cataracts. Usual nutrient intake was calculated as the average intake from 5 food-frequency questionnaires collected over a 13-15-y period before the eye examination. Duration of vitamin supplement use was determined from 7 questionnaires collected during this same period. We defined cortical opacities as grade > or = 0.5 and subcapsular opacities as grade > or =0.3 of the Lens Opacities Classification System III.
Some lenses had more than one opacity. No nutrient measure was related to prevalence of opacities in the full sample, but significant interactions were seen between age and vitamin C intake (P = 0.02) for odds of cortical opacities and between smoking status and folate (P = 0.02), alpha-carotene (P = 0.02), beta-carotene (P = 0.005), and total carotenoids (P = 0.02) for odds of PSC opacities. For women aged <60 y, a vitamin C intake > or = 362 mg/d was associated with a 57% lower odds ratio (0.43; 95% CI: 0.2, 0.93) of developing a cortical cataract than was an intake <140 mg/d, and use of vitamin C supplements for > or = 10 y was associated with a 60% lower odds ratio (0.40; 0.18, 0.87) than was no vitamin C supplement use. Prevalence of PSC opacities was related to total carotenoid intake in women who never smoked (P = 0.02).
Our results support a role for vitamin C in diminishing the risk of cortical cataracts in women aged <60 y and for carotenoids in diminishing the risk of PSC cataracts in women who have never smoked.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>11864861</pmid><doi>10.1093/ajcn/75.3.540</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aging - drug effects Antioxidants - administration & dosage Antioxidants - analysis Ascorbic Acid - administration & dosage Biological and medical sciences Carotenoids - administration & dosage Carotenoids - blood Cataract - epidemiology Cataract - etiology Cataract - prevention & control Cataracts Cohort Studies Diet Surveys Dietary Supplements Female Humans Lens diseases Lens Nucleus, Crystalline - drug effects Longitudinal Studies Medical sciences Middle Aged Nutrition Nutrition Assessment Odds Ratio Ophthalmology Prevalence Prospective Studies Smoking Surveys and Questionnaires United States - epidemiology Vitamins Vitamins - administration & dosage Vitamins - blood Women Women's Health |
| title | Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities |
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