P Fimbria–Specific B Cell Responses in Patients with Urinary Tract Infection
Local immune response may be important in defense against urinary tract infection (UTI). P fimbria, an important virulence factor of Escherichia coli is a noteworthy candidate for use in a vaccine against pyelonephritis (PN). Eleven patients with PN and 14 patients with lower urinary tract infection...
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| Veröffentlicht in: | The Journal of infectious diseases 2003-12, Vol.188 (12), p.1885-1891 |
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| container_end_page | 1891 |
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| container_issue | 12 |
| container_start_page | 1885 |
| container_title | The Journal of infectious diseases |
| container_volume | 188 |
| creator | Kantele, Anu Möttönen, Timo Ala-Kaila, Kyösti Arvilommi, Heikki S. |
| description | Local immune response may be important in defense against urinary tract infection (UTI). P fimbria, an important virulence factor of Escherichia coli is a noteworthy candidate for use in a vaccine against pyelonephritis (PN). Eleven patients with PN and 14 patients with lower urinary tract infection (LUTI) caused by E. coli were studied for mucosa-derived antibody-secreting cells (ASCs) and for urinary antibodies. In the 10 patients with P-fimbriated (P+) E. coli an ASC response to P fimbria was found in 5 of 5 patients who had PN and 1 of 5 patients who had LUTI. The response to P fimbria was stronger among patients with P+ PN than among patients with PN caused by non–P-fimbriated E. coli (P−) (P |
| doi_str_mv | 10.1086/380097 |
| format | Article |
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P fimbria, an important virulence factor of Escherichia coli is a noteworthy candidate for use in a vaccine against pyelonephritis (PN). Eleven patients with PN and 14 patients with lower urinary tract infection (LUTI) caused by E. coli were studied for mucosa-derived antibody-secreting cells (ASCs) and for urinary antibodies. In the 10 patients with P-fimbriated (P+) E. coli an ASC response to P fimbria was found in 5 of 5 patients who had PN and 1 of 5 patients who had LUTI. The response to P fimbria was stronger among patients with P+ PN than among patients with PN caused by non–P-fimbriated E. coli (P−) (P<.001) or patients with P+ LUTI (P<.001). The response to P fimbria was also stronger than the response to outer-membrane protein A among all patients with PN. P fimbria–specific urinary immunoglobulin A antibody levels were higher among patients with P+ PN than those with P− PN. The results show a P fimbria–specific local immune response, which further encourages the use of P fimbria in locally administrable UTI vaccines</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/380097</identifier><identifier>PMID: 14673769</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies ; Antibodies, Bacterial - urine ; Antigens ; B lymphocytes ; B-Lymphocytes - immunology ; Bacteria ; Bacterial Outer Membrane Proteins - immunology ; Biological and medical sciences ; Blood ; Escherichia coli ; Escherichia coli Infections - immunology ; Escherichia coli Infections - prevention & control ; Escherichia coli Infections - urine ; Escherichia coli Proteins - immunology ; Female ; Fimbriae ; Fimbriae, Bacterial - immunology ; Fundamental and applied biological sciences. Psychology ; Humans ; Immune response ; Infectious diseases ; Leukocyte Count ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Mucous Membrane - immunology ; Pyelonephritis - immunology ; Urinary tract infections ; Urinary Tract Infections - immunology ; Urinary Tract Infections - prevention & control ; Urinary Tract Infections - urine ; Urine ; Vaccination</subject><ispartof>The Journal of infectious diseases, 2003-12, Vol.188 (12), p.1885-1891</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-7718625846c6d432e029a726ea73277b4e18e00e0b113e63b3749f9dee7526203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30076787$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30076787$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15411683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14673769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kantele, Anu</creatorcontrib><creatorcontrib>Möttönen, Timo</creatorcontrib><creatorcontrib>Ala-Kaila, Kyösti</creatorcontrib><creatorcontrib>Arvilommi, Heikki S.</creatorcontrib><title>P Fimbria–Specific B Cell Responses in Patients with Urinary Tract Infection</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Local immune response may be important in defense against urinary tract infection (UTI). P fimbria, an important virulence factor of Escherichia coli is a noteworthy candidate for use in a vaccine against pyelonephritis (PN). Eleven patients with PN and 14 patients with lower urinary tract infection (LUTI) caused by E. coli were studied for mucosa-derived antibody-secreting cells (ASCs) and for urinary antibodies. In the 10 patients with P-fimbriated (P+) E. coli an ASC response to P fimbria was found in 5 of 5 patients who had PN and 1 of 5 patients who had LUTI. The response to P fimbria was stronger among patients with P+ PN than among patients with PN caused by non–P-fimbriated E. coli (P−) (P<.001) or patients with P+ LUTI (P<.001). The response to P fimbria was also stronger than the response to outer-membrane protein A among all patients with PN. P fimbria–specific urinary immunoglobulin A antibody levels were higher among patients with P+ PN than those with P− PN. The results show a P fimbria–specific local immune response, which further encourages the use of P fimbria in locally administrable UTI vaccines</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - urine</subject><subject>Antigens</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacteria</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - immunology</subject><subject>Escherichia coli Infections - prevention & control</subject><subject>Escherichia coli Infections - urine</subject><subject>Escherichia coli Proteins - immunology</subject><subject>Female</subject><subject>Fimbriae</subject><subject>Fimbriae, Bacterial - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infectious diseases</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mucous Membrane - immunology</subject><subject>Pyelonephritis - immunology</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - immunology</subject><subject>Urinary Tract Infections - prevention & control</subject><subject>Urinary Tract Infections - urine</subject><subject>Urine</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFu1DAQBmALgei2wBuAzAFugbEnsZ0jrGi3UoEKWgn1YjneiXDZTYLtVeHWd-AN-yTNKqvuiZMP_6eZ8c_YCwHvBBj1Hg1ArR-xmahQF0oJfMxmAFIWwtT1ATtM6RoASlT6KTsQpdKoVT1jX875cVg3Mbi723_fB_KhDZ5_5HNarfg3SkPfJUo8dPzc5UBdTvwm5J_8MobOxb_8Ijqf-WnXks-h756xJ61bJXq-e4_Y5fGni_miOPt6cjr_cFb4UmIutBZGycqUyqtliZJA1k5LRU6j1LopSRgCIGiEQFLYoC7rtl4S6UoqCXjE3k5zh9j_3lDKdh2SH292HfWbZPX4Q1lV1R762KcUqbVDDOvxcivAbpuzU3MjfLWbuGnWtNyzXVUjeLMDLnm3aqPrfEh7V5VCKIOjez25fjP8f9nLyVyn3McHhQBaabPNiykPKdOfh9zFX3Z7TWUXP66s_IxGiMWVRbwHt3uV0A</recordid><startdate>20031215</startdate><enddate>20031215</enddate><creator>Kantele, Anu</creator><creator>Möttönen, Timo</creator><creator>Ala-Kaila, Kyösti</creator><creator>Arvilommi, Heikki S.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031215</creationdate><title>P Fimbria–Specific B Cell Responses in Patients with Urinary Tract Infection</title><author>Kantele, Anu ; Möttönen, Timo ; Ala-Kaila, Kyösti ; Arvilommi, Heikki S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-7718625846c6d432e029a726ea73277b4e18e00e0b113e63b3749f9dee7526203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - urine</topic><topic>Antigens</topic><topic>B lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacteria</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - immunology</topic><topic>Escherichia coli Infections - prevention & control</topic><topic>Escherichia coli Infections - urine</topic><topic>Escherichia coli Proteins - immunology</topic><topic>Female</topic><topic>Fimbriae</topic><topic>Fimbriae, Bacterial - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immune response</topic><topic>Infectious diseases</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mucous Membrane - immunology</topic><topic>Pyelonephritis - immunology</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - immunology</topic><topic>Urinary Tract Infections - prevention & control</topic><topic>Urinary Tract Infections - urine</topic><topic>Urine</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kantele, Anu</creatorcontrib><creatorcontrib>Möttönen, Timo</creatorcontrib><creatorcontrib>Ala-Kaila, Kyösti</creatorcontrib><creatorcontrib>Arvilommi, Heikki S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kantele, Anu</au><au>Möttönen, Timo</au><au>Ala-Kaila, Kyösti</au><au>Arvilommi, Heikki S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P Fimbria–Specific B Cell Responses in Patients with Urinary Tract Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2003-12-15</date><risdate>2003</risdate><volume>188</volume><issue>12</issue><spage>1885</spage><epage>1891</epage><pages>1885-1891</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Local immune response may be important in defense against urinary tract infection (UTI). P fimbria, an important virulence factor of Escherichia coli is a noteworthy candidate for use in a vaccine against pyelonephritis (PN). Eleven patients with PN and 14 patients with lower urinary tract infection (LUTI) caused by E. coli were studied for mucosa-derived antibody-secreting cells (ASCs) and for urinary antibodies. In the 10 patients with P-fimbriated (P+) E. coli an ASC response to P fimbria was found in 5 of 5 patients who had PN and 1 of 5 patients who had LUTI. The response to P fimbria was stronger among patients with P+ PN than among patients with PN caused by non–P-fimbriated E. coli (P−) (P<.001) or patients with P+ LUTI (P<.001). The response to P fimbria was also stronger than the response to outer-membrane protein A among all patients with PN. P fimbria–specific urinary immunoglobulin A antibody levels were higher among patients with P+ PN than those with P− PN. The results show a P fimbria–specific local immune response, which further encourages the use of P fimbria in locally administrable UTI vaccines</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14673769</pmid><doi>10.1086/380097</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2003-12, Vol.188 (12), p.1885-1891 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antibodies Antibodies, Bacterial - urine Antigens B lymphocytes B-Lymphocytes - immunology Bacteria Bacterial Outer Membrane Proteins - immunology Biological and medical sciences Blood Escherichia coli Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Escherichia coli Infections - urine Escherichia coli Proteins - immunology Female Fimbriae Fimbriae, Bacterial - immunology Fundamental and applied biological sciences. Psychology Humans Immune response Infectious diseases Leukocyte Count Male Medical sciences Microbiology Middle Aged Mucous Membrane - immunology Pyelonephritis - immunology Urinary tract infections Urinary Tract Infections - immunology Urinary Tract Infections - prevention & control Urinary Tract Infections - urine Urine Vaccination |
| title | P Fimbria–Specific B Cell Responses in Patients with Urinary Tract Infection |
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