Stimulation of non-hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity

Stimulation by CD40 ligand (L) improves B-cell malignancy immunogenicity, and also induces proliferative signals. To avoid these tumorigenic effects, we studied an alternate way of tumor-cell stimulation by homologous to lymphotoxin, inducible expression, competing for GpD of herpesvirus, which bind...

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Veröffentlicht in:	Leukemia 2003-12, Vol.17 (12), p.2500-2507
Hauptverfasser:	COSTELLO, R. T, MALLET, F, BARBARAT, B, DE COLELLA, J-M Schiano, SAINTY, D, SWEET, R. W, TRUNEH, A, OLIVE, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Apoptosis - immunology B-cell lymphoma B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences Cancer CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - secretion CD40 antigen CD40 Antigens - metabolism CD40L protein Cell Adhesion - immunology Cell Death - immunology Cell Division - immunology Cell recognition Chemotherapy Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism fas Receptor - metabolism Gene Expression Hematologic and hematopoietic diseases Herpes viruses Homology Humans Immunogenicity Immunotherapy Interleukin-2 - secretion Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Ligands Light Lymphocyte Culture Test, Mixed Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Lymphoma, Mantle-Cell - immunology Lymphoma, Mantle-Cell - therapy Lymphoma, Non-Hodgkin - immunology Lymphoma, Non-Hodgkin - therapy Lymphotoxin Malignancy Mantle cell lymphoma Medical sciences Non-Hodgkin's lymphoma Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor, Member 14 Receptors, Virus - genetics Sensitivity enhancement Stimulation Transfection Tumor cells Tumor necrosis factor Tumor necrosis factor receptors Tumor necrosis factor-TNF
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