Bisphosphonates Pamidronate and Zoledronic Acid Stimulate Osteoprotegerin Production by Primary Human Osteoblasts

Bisphosphonates are potent antiresorptive drugs commonly employed in the treatment of metabolic bone diseases. Despite their frequent use, the mechanisms of bisphosphonates on bone cells have largely remained unclear. Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-03, Vol.291 (3), p.680-686
Hauptverfasser:	Viereck, Volker, Emons, Günter, Lauck, Vanessa, Frosch, Karl-Heinz, Blaschke, Sabine, Gründker, Carsten, Hofbauer, Lorenz C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - analysis bisphosphonates Cell Differentiation Cells, Cultured Collagen Type I - biosynthesis Dexamethasone - antagonists & inhibitors Diphosphonates - pharmacology Dose-Response Relationship, Drug Glucocorticoids - antagonists & inhibitors Glycoproteins - biosynthesis Glycoproteins - genetics Humans Imidazoles - pharmacology Kinetics osteoblast Osteoblasts - drug effects Osteoblasts - metabolism osteoclast Osteoprotegerin Protein Biosynthesis RANKL Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - genetics Receptors, Tumor Necrosis Factor RNA, Messenger - biosynthesis Transcriptional Activation
Online-Zugang:	Volltext
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