The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V1a receptor mRNA
Objective To investigate labour‐associated changes in: 1. the myometrial contractile response to arginine vasopressin compared with oxytocin in vitro 2. fetal production of arginine vasopressin and 3. myometrial vasopressin V1a receptor mRNA. Design The contractile response to vasopressin (compared...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2002-01, Vol.109 (1), p.57-62 |
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| creator | Thornton, S. Baldwin, P.J. Harris, P.A. Harding, F. Davison, J.M. Baylis, P.H. Timmons, P.M. Wathes, D.C. |
| description | Objective
To investigate labour‐associated changes in: 1. the myometrial contractile response to arginine vasopressin compared with oxytocin in vitro 2. fetal production of arginine vasopressin and 3. myometrial vasopressin V1a receptor mRNA.
Design
The contractile response to vasopressin (compared with oxytocin) was investigated in paired myometrial strips in vitro. Blood was taken from the umbilical artery and vein at delivery and arginine vasopressin measured by radio‐immunoassay. V1a receptor mRNA was determined by in situ hybridisation.
Results
Myometrium was more sensitive to arginine vasopressin than oxytocin (P |
| doi_str_mv | 10.1111/j.1471-0528.2002.01132.x |
| format | Article |
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To investigate labour‐associated changes in: 1. the myometrial contractile response to arginine vasopressin compared with oxytocin in vitro 2. fetal production of arginine vasopressin and 3. myometrial vasopressin V1a receptor mRNA.
Design
The contractile response to vasopressin (compared with oxytocin) was investigated in paired myometrial strips in vitro. Blood was taken from the umbilical artery and vein at delivery and arginine vasopressin measured by radio‐immunoassay. V1a receptor mRNA was determined by in situ hybridisation.
Results
Myometrium was more sensitive to arginine vasopressin than oxytocin (P <0.05 for frequency, amplitude and activity integral in paired strips) after, but not before labour. There was a marked umbilical arteriovenous difference in arginine vasopressin concentration at delivery suggesting fetal production which was not influenced by labour. Myometrial vasopressin V1a receptor mRNA was not increased after the onset of labour.
Conclusions
The human uterus is extremely sensitive to arginine vasopressin in vitro. Arginine vasopressin is produced by the fetus but fetal formation is not increased during labour.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2002.01132.x</identifier><identifier>PMID: 11843375</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Arginine Vasopressin - metabolism ; Arginine Vasopressin - physiology ; Biological and medical sciences ; Delivery. Postpartum. Lactation ; Dose-Response Relationship, Drug ; Female ; Fetal Blood - chemistry ; Fetus - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; In Situ Hybridization ; Labor, Obstetric - metabolism ; Maternal, fetal and perinatal monitoring ; Medical sciences ; Myometrium - metabolism ; Oxytocics - pharmacology ; Oxytocin - pharmacology ; Pregnancy ; Receptors, Vasopressin - metabolism ; RNA, Messenger - metabolism ; Uterine Contraction - physiology</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2002-01, Vol.109 (1), p.57-62</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2002.01132.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2002.01132.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13448057$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11843375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thornton, S.</creatorcontrib><creatorcontrib>Baldwin, P.J.</creatorcontrib><creatorcontrib>Harris, P.A.</creatorcontrib><creatorcontrib>Harding, F.</creatorcontrib><creatorcontrib>Davison, J.M.</creatorcontrib><creatorcontrib>Baylis, P.H.</creatorcontrib><creatorcontrib>Timmons, P.M.</creatorcontrib><creatorcontrib>Wathes, D.C.</creatorcontrib><title>The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V1a receptor mRNA</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To investigate labour‐associated changes in: 1. the myometrial contractile response to arginine vasopressin compared with oxytocin in vitro 2. fetal production of arginine vasopressin and 3. myometrial vasopressin V1a receptor mRNA.
Design
The contractile response to vasopressin (compared with oxytocin) was investigated in paired myometrial strips in vitro. Blood was taken from the umbilical artery and vein at delivery and arginine vasopressin measured by radio‐immunoassay. V1a receptor mRNA was determined by in situ hybridisation.
Results
Myometrium was more sensitive to arginine vasopressin than oxytocin (P <0.05 for frequency, amplitude and activity integral in paired strips) after, but not before labour. There was a marked umbilical arteriovenous difference in arginine vasopressin concentration at delivery suggesting fetal production which was not influenced by labour. Myometrial vasopressin V1a receptor mRNA was not increased after the onset of labour.
Conclusions
The human uterus is extremely sensitive to arginine vasopressin in vitro. Arginine vasopressin is produced by the fetus but fetal formation is not increased during labour.</description><subject>Adult</subject><subject>Arginine Vasopressin - metabolism</subject><subject>Arginine Vasopressin - physiology</subject><subject>Biological and medical sciences</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fetus - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Labor, Obstetric - metabolism</subject><subject>Maternal, fetal and perinatal monitoring</subject><subject>Medical sciences</subject><subject>Myometrium - metabolism</subject><subject>Oxytocics - pharmacology</subject><subject>Oxytocin - pharmacology</subject><subject>Pregnancy</subject><subject>Receptors, Vasopressin - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Uterine Contraction - physiology</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd1u1DAQhS0EoqXwCsg3cEWCx3ZiLxIXpeJXFZVQ4daaTWzqVWKndgKtxMPjbBdqWfKMz6fRzBxCKLAaynm9q0EqqFjDdc0Z4zUDELy-eUCO_wsP9zGrmOD6iDzJeccYtJyJx-QIQEshVHNM_lxeWZriYGl0FNNPH3yw9BfmOCWbsw-03KtlxEAH3MYlvaFuCd3sY8CB5nnpvc2vqLNzSacU-2WvUQw9HWKHg8-4_yjlfwDSZDs7zTHR8dvX06fkkcMh22eH94R8__D-8uxTdX7x8fPZ6Xk1cdbyqodecLYFB0poxzbM9l3TgFay6TvUqO1m45RkHToNttkIwaXiDpt2K1teNnNCXt7VLQ1eLzbPZvS5s8OAwcYlGwWyBQVtAZ8fwGU72t5MyY-Ybs2_fRXgxQHAXIZzCUPn8z0npNSsUYV7e8f99oO9vdeZWf0zO7PaZFabzOqf2ftnbsy7LxdrJP4CXmaN6Q</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Thornton, S.</creator><creator>Baldwin, P.J.</creator><creator>Harris, P.A.</creator><creator>Harding, F.</creator><creator>Davison, J.M.</creator><creator>Baylis, P.H.</creator><creator>Timmons, P.M.</creator><creator>Wathes, D.C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V1a receptor mRNA</title><author>Thornton, S. ; Baldwin, P.J. ; Harris, P.A. ; Harding, F. ; Davison, J.M. ; Baylis, P.H. ; Timmons, P.M. ; Wathes, D.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2062-d1d320b1f1738f090edc5518745dca8a8e99f740caf81e59332472fa56b462113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Arginine Vasopressin - metabolism</topic><topic>Arginine Vasopressin - physiology</topic><topic>Biological and medical sciences</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fetus - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Labor, Obstetric - metabolism</topic><topic>Maternal, fetal and perinatal monitoring</topic><topic>Medical sciences</topic><topic>Myometrium - metabolism</topic><topic>Oxytocics - pharmacology</topic><topic>Oxytocin - pharmacology</topic><topic>Pregnancy</topic><topic>Receptors, Vasopressin - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Uterine Contraction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thornton, S.</creatorcontrib><creatorcontrib>Baldwin, P.J.</creatorcontrib><creatorcontrib>Harris, P.A.</creatorcontrib><creatorcontrib>Harding, F.</creatorcontrib><creatorcontrib>Davison, J.M.</creatorcontrib><creatorcontrib>Baylis, P.H.</creatorcontrib><creatorcontrib>Timmons, P.M.</creatorcontrib><creatorcontrib>Wathes, D.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thornton, S.</au><au>Baldwin, P.J.</au><au>Harris, P.A.</au><au>Harding, F.</au><au>Davison, J.M.</au><au>Baylis, P.H.</au><au>Timmons, P.M.</au><au>Wathes, D.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V1a receptor mRNA</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2002-01</date><risdate>2002</risdate><volume>109</volume><issue>1</issue><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Objective
To investigate labour‐associated changes in: 1. the myometrial contractile response to arginine vasopressin compared with oxytocin in vitro 2. fetal production of arginine vasopressin and 3. myometrial vasopressin V1a receptor mRNA.
Design
The contractile response to vasopressin (compared with oxytocin) was investigated in paired myometrial strips in vitro. Blood was taken from the umbilical artery and vein at delivery and arginine vasopressin measured by radio‐immunoassay. V1a receptor mRNA was determined by in situ hybridisation.
Results
Myometrium was more sensitive to arginine vasopressin than oxytocin (P <0.05 for frequency, amplitude and activity integral in paired strips) after, but not before labour. There was a marked umbilical arteriovenous difference in arginine vasopressin concentration at delivery suggesting fetal production which was not influenced by labour. Myometrial vasopressin V1a receptor mRNA was not increased after the onset of labour.
Conclusions
The human uterus is extremely sensitive to arginine vasopressin in vitro. Arginine vasopressin is produced by the fetus but fetal formation is not increased during labour.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11843375</pmid><doi>10.1111/j.1471-0528.2002.01132.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Arginine Vasopressin - metabolism Arginine Vasopressin - physiology Biological and medical sciences Delivery. Postpartum. Lactation Dose-Response Relationship, Drug Female Fetal Blood - chemistry Fetus - metabolism Gynecology. Andrology. Obstetrics Humans In Situ Hybridization Labor, Obstetric - metabolism Maternal, fetal and perinatal monitoring Medical sciences Myometrium - metabolism Oxytocics - pharmacology Oxytocin - pharmacology Pregnancy Receptors, Vasopressin - metabolism RNA, Messenger - metabolism Uterine Contraction - physiology |
| title | The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V1a receptor mRNA |
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