c-kit Mutations in Gastrointestinal Stromal Tumors Occur Preferentially in the Spindle Rather Than in the Epithelioid Cell Variant

Gastrointestinal stromal tumors (GISTs) coexpress CD34 and the Kit tyrosine-kinase receptor (CD117). A subset of GISTs carry gain-of-function mutations of the c-kit proto-oncogene in its juxtamembrane domain. The relationship between the mutational status and histological as well as immunohistochemi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Modern pathology 2002-02, Vol.15 (2), p.125-136
Hauptverfasser:	Wardelmann, Eva, Neidt, Iris, Bierhoff, Erhard, Speidel, Nicola, Manegold, Christoph, Fischer, Hans-Peter, Pfeifer, Ulrich, Pietsch, Torsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino Acid Sequence Antigens, CD34 - analysis Base Sequence c-kit DNA Mutational Analysis DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Epithelioid Cells - metabolism Epithelioid Cells - pathology Female Fibroids Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - pathology Gastrointestinal stromal tumor Gastrointestinal tract Humans Immunohistochemistry Kinases KIT mutation Laboratory Medicine Male Medical prognosis Medical research Medicine Medicine & Public Health Mesenchymal tumor Middle Aged Molecular Sequence Data Morphology Mutation Mutation, Missense original-article Pathology Phenotype Polymorphism, Single-Stranded Conformational Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-kit - analysis Proto-Oncogene Proteins c-kit - genetics Sequence Deletion Sequence Homology, Amino Acid Tumors Vimentin - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!