Overexpression of Nell‐1, a Craniosynostosis‐Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development

We studied the cellular function of Nell‐1, a craniosynostosis‐related gene, in craniofacial development. Nell‐1 modulates calvarial osteoblast differentiation and apoptosis pathways. Nell‐1 overexpression disrupts these pathways resulting in craniofacial anomalies such as premature suture closure....

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Veröffentlicht in:	Journal of bone and mineral research 2003-12, Vol.18 (12), p.2126-2134
Hauptverfasser:	Zhang, Xinli, Carpenter, Dale, Bokui, Nobuyuki, Soo, Chia, Miao, Steve, Truong, Thien, WU, Benjamin, Chen, Ingrid, Vastardis, Heleni, Tanizawa, Katsuyuki, Kuroda, Shun″Ichi, Ting, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - physiology Base Sequence Biological and medical sciences Cell Death Craniofacial Abnormalities - genetics Craniosynostoses - genetics craniosynostosis Diseases of the osteoarticular system DNA Primers Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Mice Mice, Transgenic Nell-1 protein NELL‐1 Nerve Tissue Proteins - genetics Oligonucleotide Array Sequence Analysis osteoblasts Osteoblasts - cytology Osteoblasts - physiology Rats
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