Potentiation of platelet activation through the stimulation of P2X1 receptors

The platelet P2X1 purinergic receptor is a ligand‐gated ion channel that responds to ATP. The precise role of P2X1 in platelet function is unknown, though stimulation with the P2X1 agonist α,β‐Me‐ATP is known to result in platelet shape change through elevation of calcium levels. The aim of the pres...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2003-12, Vol.1 (12), p.2626-2635
Hauptverfasser:	Erhardt, J. A., Pillarisetti, K., Toomey, J. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Calcium Signaling Cell Size - drug effects Epinephrine - pharmacology Heparin - pharmacology Humans P2X1 Platelet Activation - drug effects Platelet Adhesiveness - drug effects platelet aggregation Platelet Function Tests Receptors, Purinergic P2 - drug effects Receptors, Purinergic P2 - physiology Receptors, Purinergic P2X Thrombopoietin - pharmacology α,β‐Me‐ATP
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