Genetic Evidence of Transmission of Human T Cell Lymphotropic Virus Type 1 between Spouses
Sexual transmission of human T cell lymphotropic virus type 1 (HTLV-1) is considered to be an important route of infection in adults. However, no direct evidence has been reported that supports this observation. To address this issue, sequence variations of the gp46 (envelope)-coding region of HTLV-...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-03, Vol.185 (5), p.691-695 |
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| container_issue | 5 |
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| container_title | The Journal of infectious diseases |
| container_volume | 185 |
| creator | Iga, Mutsunori Okayama, Akihiko Stuver, Sherri Matsuoka, Masao Mueller, Nancy Aoki, Manabu Mitsuya, Hiroaki Tachibana, Nobuyoshi Tsubouchi, Hirohito |
| description | Sexual transmission of human T cell lymphotropic virus type 1 (HTLV-1) is considered to be an important route of infection in adults. However, no direct evidence has been reported that supports this observation. To address this issue, sequence variations of the gp46 (envelope)-coding region of HTLV-1 were determined in 13 patients infected with HTLV-1 who experienced seroconversion and in their spouses. Twenty-two nucleotide changes that were different from the reference sequence of λATK-1 were identified. However, the gp46 sequences found were identical within each married couple. HTLV-1 proviral DNA loads measured in 11 of these couples varied from 10 to 3430 copies per 105 PBMC, and the proviral DNA loads of spouses often differed. This study provides the first genetic confirmation of the transmission of HTLV-1 from a carrier spouse to his/her partner. The findings also suggest that host-related factors play a more important role than do virus-specific factors in determining HTLV-1 proviral DNA load. |
| doi_str_mv | 10.1086/339002 |
| format | Article |
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However, no direct evidence has been reported that supports this observation. To address this issue, sequence variations of the gp46 (envelope)-coding region of HTLV-1 were determined in 13 patients infected with HTLV-1 who experienced seroconversion and in their spouses. Twenty-two nucleotide changes that were different from the reference sequence of λATK-1 were identified. However, the gp46 sequences found were identical within each married couple. HTLV-1 proviral DNA loads measured in 11 of these couples varied from 10 to 3430 copies per 105 PBMC, and the proviral DNA loads of spouses often differed. This study provides the first genetic confirmation of the transmission of HTLV-1 from a carrier spouse to his/her partner. The findings also suggest that host-related factors play a more important role than do virus-specific factors in determining HTLV-1 proviral DNA load.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/339002</identifier><identifier>PMID: 11865428</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Base Sequence ; Biological and medical sciences ; Concise Communication ; Disease transmission ; DNA ; DNA, Viral - analysis ; DNA, Viral - blood ; Gene Products, env - genetics ; HTLV-I Antibodies - blood ; HTLV-I Infections - transmission ; HTLV-I Infections - virology ; Human T lymphotropic virus 1 ; Human T-lymphotropic virus 1 - genetics ; Human viral diseases ; Humans ; Husbands ; Infections ; Infectious diseases ; Medical sciences ; Molecular Sequence Data ; Nucleotide sequences ; Pharmacology. Drug treatments ; Proviruses ; Retroviridae Proteins, Oncogenic - genetics ; Sequence Analysis, DNA ; Sexual transmission ; Spouses ; T lymphocytes ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viruses</subject><ispartof>The Journal of infectious diseases, 2002-03, Vol.185 (5), p.691-695</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Mar 1, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-d82d215a36855b4115dda8128a1dcc239925133c0431da05b4efc330e35bbed73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30137638$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30137638$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13506732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11865428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iga, Mutsunori</creatorcontrib><creatorcontrib>Okayama, Akihiko</creatorcontrib><creatorcontrib>Stuver, Sherri</creatorcontrib><creatorcontrib>Matsuoka, Masao</creatorcontrib><creatorcontrib>Mueller, Nancy</creatorcontrib><creatorcontrib>Aoki, Manabu</creatorcontrib><creatorcontrib>Mitsuya, Hiroaki</creatorcontrib><creatorcontrib>Tachibana, Nobuyoshi</creatorcontrib><creatorcontrib>Tsubouchi, Hirohito</creatorcontrib><title>Genetic Evidence of Transmission of Human T Cell Lymphotropic Virus Type 1 between Spouses</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Sexual transmission of human T cell lymphotropic virus type 1 (HTLV-1) is considered to be an important route of infection in adults. However, no direct evidence has been reported that supports this observation. To address this issue, sequence variations of the gp46 (envelope)-coding region of HTLV-1 were determined in 13 patients infected with HTLV-1 who experienced seroconversion and in their spouses. Twenty-two nucleotide changes that were different from the reference sequence of λATK-1 were identified. However, the gp46 sequences found were identical within each married couple. HTLV-1 proviral DNA loads measured in 11 of these couples varied from 10 to 3430 copies per 105 PBMC, and the proviral DNA loads of spouses often differed. This study provides the first genetic confirmation of the transmission of HTLV-1 from a carrier spouse to his/her partner. The findings also suggest that host-related factors play a more important role than do virus-specific factors in determining HTLV-1 proviral DNA load.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Concise Communication</subject><subject>Disease transmission</subject><subject>DNA</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - blood</subject><subject>Gene Products, env - genetics</subject><subject>HTLV-I Antibodies - blood</subject><subject>HTLV-I Infections - transmission</subject><subject>HTLV-I Infections - virology</subject><subject>Human T lymphotropic virus 1</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Husbands</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Nucleotide sequences</subject><subject>Pharmacology. Drug treatments</subject><subject>Proviruses</subject><subject>Retroviridae Proteins, Oncogenic - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Sexual transmission</subject><subject>Spouses</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFv0zAUhS0EYqXAPwAZpPEW8PWNE-cRVVvLVAmkFZj2YjmOI1KaONgJW_89rlJtExLiybLv53vOvYeQl8DeA5PZB8SCMf6IzEBgnmQZ4GMyiy88AVkUJ-RZCFvGWIpZ_pScAMhMpFzOyPXSdnZoDD373VS2M5a6mm687kLbhNC47nBfja3u6IYu7G5H1_u2_-EG7_r461vjx0A3-95SoKUdbqzt6GXvxmDDc_Kk1rtgXxzPOfl6frZZrJL15-Wnxcd1YlIJQ1JJXnEQGjMpRJkCiKrSErjUUBnDsSi4AEQTvUOlWURsbRCZRVGWtspxTt5NfXvvfo02DCpaN9Gq7mw0onJIM5blxX9BkCmTMi5wTt7-BW7d6Ls4hOIcZSEQHsga70Lwtla9b1rt9wqYOmSipkwi-PrYbSxbW91jxxAicHoEdDB6V8ftmybccyiifTw0ejNxbuz_LfZqYrZhcP6OQgaYZ3jQSqZ6EwZ7e1fX_qeKGrlQq6trtcQvxdX3_FJd4B_NWbNj</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Iga, Mutsunori</creator><creator>Okayama, Akihiko</creator><creator>Stuver, Sherri</creator><creator>Matsuoka, Masao</creator><creator>Mueller, Nancy</creator><creator>Aoki, Manabu</creator><creator>Mitsuya, Hiroaki</creator><creator>Tachibana, Nobuyoshi</creator><creator>Tsubouchi, Hirohito</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Genetic Evidence of Transmission of Human T Cell Lymphotropic Virus Type 1 between Spouses</title><author>Iga, Mutsunori ; Okayama, Akihiko ; Stuver, Sherri ; Matsuoka, Masao ; Mueller, Nancy ; Aoki, Manabu ; Mitsuya, Hiroaki ; Tachibana, Nobuyoshi ; Tsubouchi, Hirohito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-d82d215a36855b4115dda8128a1dcc239925133c0431da05b4efc330e35bbed73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Concise Communication</topic><topic>Disease transmission</topic><topic>DNA</topic><topic>DNA, Viral - analysis</topic><topic>DNA, Viral - blood</topic><topic>Gene Products, env - genetics</topic><topic>HTLV-I Antibodies - blood</topic><topic>HTLV-I Infections - transmission</topic><topic>HTLV-I Infections - virology</topic><topic>Human T lymphotropic virus 1</topic><topic>Human T-lymphotropic virus 1 - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Husbands</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Nucleotide sequences</topic><topic>Pharmacology. Drug treatments</topic><topic>Proviruses</topic><topic>Retroviridae Proteins, Oncogenic - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Sexual transmission</topic><topic>Spouses</topic><topic>T lymphocytes</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iga, Mutsunori</creatorcontrib><creatorcontrib>Okayama, Akihiko</creatorcontrib><creatorcontrib>Stuver, Sherri</creatorcontrib><creatorcontrib>Matsuoka, Masao</creatorcontrib><creatorcontrib>Mueller, Nancy</creatorcontrib><creatorcontrib>Aoki, Manabu</creatorcontrib><creatorcontrib>Mitsuya, Hiroaki</creatorcontrib><creatorcontrib>Tachibana, Nobuyoshi</creatorcontrib><creatorcontrib>Tsubouchi, Hirohito</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iga, Mutsunori</au><au>Okayama, Akihiko</au><au>Stuver, Sherri</au><au>Matsuoka, Masao</au><au>Mueller, Nancy</au><au>Aoki, Manabu</au><au>Mitsuya, Hiroaki</au><au>Tachibana, Nobuyoshi</au><au>Tsubouchi, Hirohito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Evidence of Transmission of Human T Cell Lymphotropic Virus Type 1 between Spouses</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>185</volume><issue>5</issue><spage>691</spage><epage>695</epage><pages>691-695</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Sexual transmission of human T cell lymphotropic virus type 1 (HTLV-1) is considered to be an important route of infection in adults. However, no direct evidence has been reported that supports this observation. To address this issue, sequence variations of the gp46 (envelope)-coding region of HTLV-1 were determined in 13 patients infected with HTLV-1 who experienced seroconversion and in their spouses. Twenty-two nucleotide changes that were different from the reference sequence of λATK-1 were identified. However, the gp46 sequences found were identical within each married couple. HTLV-1 proviral DNA loads measured in 11 of these couples varied from 10 to 3430 copies per 105 PBMC, and the proviral DNA loads of spouses often differed. This study provides the first genetic confirmation of the transmission of HTLV-1 from a carrier spouse to his/her partner. The findings also suggest that host-related factors play a more important role than do virus-specific factors in determining HTLV-1 proviral DNA load.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11865428</pmid><doi>10.1086/339002</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2002-03, Vol.185 (5), p.691-695 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71460679 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Base Sequence Biological and medical sciences Concise Communication Disease transmission DNA DNA, Viral - analysis DNA, Viral - blood Gene Products, env - genetics HTLV-I Antibodies - blood HTLV-I Infections - transmission HTLV-I Infections - virology Human T lymphotropic virus 1 Human T-lymphotropic virus 1 - genetics Human viral diseases Humans Husbands Infections Infectious diseases Medical sciences Molecular Sequence Data Nucleotide sequences Pharmacology. Drug treatments Proviruses Retroviridae Proteins, Oncogenic - genetics Sequence Analysis, DNA Sexual transmission Spouses T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viruses |
| title | Genetic Evidence of Transmission of Human T Cell Lymphotropic Virus Type 1 between Spouses |
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