A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins

We have identified a new first step in the hormonal activation of the glucocorticoid receptor (GR). Rather than causing immediate dissociation of the cytoplasmic GR heterocomplex, binding of hormone-induced substitution of one immunophilin (FKBP51) for another (FKBP52), and concomitant recruitment o...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (7), p.4597-4600
Hauptverfasser:	Davies, Todd H, Ning, Yang-Min, Sánchez, Edwin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Blotting, Western Cytoplasm - metabolism Cytosol - metabolism Dyneins - metabolism Electrophoresis, Polyacrylamide Gel Fibroblasts - metabolism FKBP51 protein FKBP52 protein HSP90 Heat-Shock Proteins - metabolism immunophilins Mice Microscopy, Fluorescence Models, Biological Protein Binding Receptors, Glucocorticoid - metabolism Signal Transduction Subcellular Fractions - metabolism Tacrolimus Binding Proteins - metabolism Tacrolimus Binding Proteins - physiology
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