Pro-erectile Effect of Vardenafil: In Vitro Experiments in Rabbits and In Vivo Comparison with Sildenafil in Rats

Objectives: To assess pro-erectile responses to vardenafil, a new selective PDE5 inhibitor, in vitro in isolated rabbit corpora cavernosa, and in vivo in anaesthetized rats. Methods: Rabbit cavernosal strips were precontracted with 10 μM phenylephrine. Dose-response relaxation curves to cumulative d...

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Veröffentlicht in:	European urology 2003-12, Vol.44 (6), p.731-736
Hauptverfasser:	Giuliano, F, Bernabe, J, Alexandre, L, Niewoehner, U, Haning, H, Bischoff, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Corpus cavernosum Culture Techniques Disease Models, Animal Dose-Response Relationship, Drug Erectile dysfunction Genital system. Reproduction Gynecology. Andrology. Obstetrics Imidazoles - pharmacology In vitro In vivo Male Male genital diseases Medical sciences Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Non tumoral diseases PDE5 inhibitor Penile erection Penile Erection - drug effects Penile Erection - physiology Pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Probability Purines Rabbits Rats Rats, Sprague-Dawley Sensitivity and Specificity Sildenafil Sildenafil Citrate Sulfones Triazines Vardenafil Vardenafil Dihydrochloride
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