Human α-Synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine

α-Synuclein is a major component of Lewy bodies found in the brains of patients with Parkinson's disease (PD). Two point mutations in α-synuclein (A53T and A30P) are identified in few families with dominantly inherited PD. Yet the mechanism by which this protein is involved in nigral cell death...

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Veröffentlicht in:	Neuroscience letters 2002-03, Vol.320 (3), p.146-150
Hauptverfasser:	Junn, Eunsung, Mouradian, M.Maral
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Biological and medical sciences Cell death Cell Death - drug effects Cell Death - genetics Cell Survival - drug effects Cell Survival - genetics Cells, Cultured - drug effects Cells, Cultured - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Dopamine - metabolism Dopamine - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genes, Reporter Humans Medical sciences Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Neurons - metabolism Neurons - pathology Oxidative Stress - drug effects Oxidative Stress - genetics Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - physiopathology Parkinson's disease Point Mutation - physiology Protein Isoforms Reactive oxygen species Reactive Oxygen Species - metabolism Substantia Nigra - metabolism Substantia Nigra - pathology Synucleins α-Synuclein
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