Molecular Cloning, Gene Localization, and Structure of Human Cyclin B3

Here we describe the molecular cloning of human cyclin B3, its localization, and its structure. It is localized in the subcentromeric region of the X chromosome, still not completely sequenced by the Human Genome Project. This cyclin B3 is unusually large for a mitotic cyclin. Its mRNAs were found i...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-02, Vol.291 (2), p.406-413
Hauptverfasser:	Lozano, Jean-Claude, Perret, Eric, Schatt, Philippe, Arnould, Cécile, Peaucellier, Gérard, Picard, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Base Sequence cell cycle Chromosome Mapping Cloning, Molecular Cyclin B - biosynthesis Cyclin B - chemistry Cyclin B - genetics cyclin B1 cyclin B2 cyclin B3 Cyclins - biosynthesis Cyclins - chemistry Cyclins - genetics Exons gene structure human Humans In Situ Hybridization, Fluorescence Introns Male Molecular Sequence Data RNA, Messenger - biosynthesis Sequence Alignment splice variants Testis - metabolism Tissue Distribution X Chromosome
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Zusammenfassung:	Here we describe the molecular cloning of human cyclin B3, its localization, and its structure. It is localized in the subcentromeric region of the X chromosome, still not completely sequenced by the Human Genome Project. This cyclin B3 is unusually large for a mitotic cyclin. Its mRNAs were found in all tissues and were particularly abundant in testis. At least three splice variants were found in the ORF and three variants in the 5′UTR.
ISSN:	0006-291X 1090-2104
DOI:	10.1006/bbrc.2002.6458