Inhibition of Cyclic Strain-Induced Endothelin-1 Gene Expression by Resveratrol

ABSTRACT—Resveratrol is a phytoestrogen naturally found in grapes and is among the major constituents of wine thought to have a cardioprotective effect. Endothelin-1 (ET-1) is a potent vasopressor synthesized by endothelial cells both in culture and in vivo. The aims of this study were to test the h...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-12, Vol.42 (6), p.1198-1205
Hauptverfasser:	Liu, Ju-Chi, Chen, Jin-Jer, Chan, Paul, Cheng, Ching-Feng, Cheng, Tzu-Hurng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Endothelin-1 - biosynthesis Endothelin-1 - genetics Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Humans Medical sciences Mitogen-Activated Protein Kinases - metabolism NADPH Oxidases - metabolism Periodicity Reactive Oxygen Species - metabolism RNA, Messenger - biosynthesis Stilbenes - pharmacology Stress, Mechanical Transcription Factor AP-1 - metabolism Transcription, Genetic - drug effects
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