Adiposity Is Related to Gender Differences in Impaired Stress-Induced Pressure Natriuresis

ABSTRACT—The purpose of this study was to determine if there are gender differences in stress-induced pressure natriuresis and to examine the effects of adiposity on these differences. The subjects were 151 boys and 141 girls 15 to 18 years of age who underwent a 5-hour stress protocol (2-hour prestress, 1-hour stress, 2-hour poststress) after being brought into similar levels of sodium balance. The gender-by-condition interaction was significant for systolic and diastolic blood pressure (P =0.001 for both), and the effect of condition was significant for sodium excretion (P =0.001). Systolic blood pressure was higher for boys throughout the protocol (P =0.001 for each) and correlated with body mass index at each condition (range in r =0.28 to 0.35; P