Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression

Mammalian cells express two homologs of the SWI2 subunit of the SWI/SNF chromatin-remodeling complex called BRG1 and BRM. Whether the SWI/SNF complexes formed by these two subunits perform identical or different functions remains an important question. In this report, we show concomitant down-regula...

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Veröffentlicht in:	Oncogene 2002-02, Vol.21 (8), p.1196-1207
Hauptverfasser:	REISMAN, David N, STROBECK, Matthew W, BETZ, Bryan L, SCIARIOTTA, Janiece, FUNKHOUSER, William JR, MURCHARDT, Christian, YANIV, Moshe, SHERMAN, Larry S, KNUDSEN, Erik S, WEISSMAN, Bernard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western BRG1 protein Cancer CD44 antigen Cell Cycle Chromatin remodeling Cyclin A Cyclin A - metabolism DNA - biosynthesis DNA Helicases Down-Regulation Drosophila Proteins Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene mutations Genetic aspects Genetic regulation Glycoproteins Health aspects Humans Hyaluronan Receptors - metabolism Immunohistochemistry Mammalian cells Mice Molecular and cellular biology mRNA Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Retinoblastoma Protein - metabolism Ribonucleoprotein, U1 Small Nuclear - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor cell lines Tumor Cells, Cultured Tumors
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