An Immunohistochemical Approach to Monitor the Prolactin-induced Activation of the JAK2/STAT5 Pathway in Pancreatic Islets of Langerhans

This study examined whether an immunohistochemical method examining the subcellular localization of STAT5 could be used to characterize the activation of the JAK2/STAT5 pathway by prolactin (PRL) in intact cells or tissues. In the Ins-1 β-cell line, STAT5A and STAT5B were distributed almost equally...

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Veröffentlicht in:	The journal of histochemistry and cytochemistry 2002-03, Vol.50 (3), p.365-383
Hauptverfasser:	Brelje, T. Clark, Svensson, Annika M, Stout, Laurence E, Bhagroo, Nicholas V, Sorenson, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - drug effects Blotting, Western Cell Nucleus - metabolism Cytoplasm - metabolism DNA-Binding Proteins - analysis DNA-Binding Proteins - metabolism Enzyme Activation - drug effects Glucagon - analysis Immunohistochemistry Insulin - analysis Insulinoma Islets of Langerhans - chemistry Islets of Langerhans - metabolism Islets of Langerhans - ultrastructure Janus Kinase 2 Microscopy, Confocal Milk Proteins Pancreatic Neoplasms Phosphorylation Phosphotyrosine - metabolism Prolactin - pharmacology Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Rats Receptors, Prolactin - analysis Somatostatin - analysis STAT5 Transcription Factor Trans-Activators - analysis Trans-Activators - metabolism Tumor Cells, Cultured
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