In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation
The distribution and functional characteristics of in vitro bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU...
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| creator | LANZA, F CAMPIONI, D PUNTURIERI, M MORETTI, S DABUSTI, M SPANEDDA, R CASTOLDI, G |
| description | The distribution and functional characteristics of in vitro bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10(6) BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (P=0.04), and in normal subjects (P=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (P=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4-6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte-macrophage (CFU-GM) (P=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (P=0.044). These in vitro data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function. |
| doi_str_mv | 10.1038/sj.bmt.1704279 |
| format | Article |
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The mean number of CFU-En/10(6) BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (P=0.04), and in normal subjects (P=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (P=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4-6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte-macrophage (CFU-GM) (P=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (P=0.044). These in vitro data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1704279</identifier><identifier>PMID: 14647271</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Angiogenesis ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Biomarkers ; Bone marrow ; Bone Marrow Cells - cytology ; Bone marrow transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; Cell Lineage ; Cells, Cultured - cytology ; Chemotherapy ; Colonies ; Colony-Forming Units Assay ; Combined Modality Therapy ; Endothelial cells ; Endothelial Cells - cytology ; Female ; Hematologic and hematopoietic diseases ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hemopoiesis ; Hodgkin's disease ; Humans ; Immunophenotyping ; Immunosuppressive agents ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocytes (granulocytic) ; Leukocytes (mononuclear) ; Lymphoma ; Lymphoma, Non-Hodgkin - drug therapy ; Lymphoma, Non-Hodgkin - pathology ; Lymphoma, Non-Hodgkin - therapy ; Macrophages ; Male ; Medical sciences ; Mesenchyme ; Middle Aged ; Non-Hodgkin's lymphoma ; Peripheral blood ; Peripheral Blood Stem Cell Transplantation ; Physiological aspects ; Progenitor cells ; Remission ; Remission Induction ; Stem cell transplantation ; Stem cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation, Autologous ; Transplantation, Homologous</subject><ispartof>Bone marrow transplantation (Basingstoke), 2003-12, Vol.32 (12), p.1165-1173</ispartof><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2003</rights><rights>Nature Publishing Group 2003.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-be1a1dc5dc5c45396f098f7c3fa5f428c6e1959558223f52b841ce4383e3066d3</citedby><cites>FETCH-LOGICAL-c505t-be1a1dc5dc5c45396f098f7c3fa5f428c6e1959558223f52b841ce4383e3066d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15354779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14647271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANZA, F</creatorcontrib><creatorcontrib>CAMPIONI, D</creatorcontrib><creatorcontrib>PUNTURIERI, M</creatorcontrib><creatorcontrib>MORETTI, S</creatorcontrib><creatorcontrib>DABUSTI, M</creatorcontrib><creatorcontrib>SPANEDDA, R</creatorcontrib><creatorcontrib>CASTOLDI, G</creatorcontrib><title>In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>The distribution and functional characteristics of in vitro bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10(6) BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (P=0.04), and in normal subjects (P=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (P=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4-6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte-macrophage (CFU-GM) (P=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (P=0.044). 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Graft versus host reaction</subject><subject>Care and treatment</subject><subject>Cell Lineage</subject><subject>Cells, Cultured - cytology</subject><subject>Chemotherapy</subject><subject>Colonies</subject><subject>Colony-Forming Units Assay</subject><subject>Combined Modality Therapy</subject><subject>Endothelial cells</subject><subject>Endothelial Cells - cytology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hemopoiesis</subject><subject>Hodgkin's disease</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Immunosuppressive agents</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocytes (granulocytic)</subject><subject>Leukocytes (mononuclear)</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - drug therapy</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Lymphoma, Non-Hodgkin - therapy</subject><subject>Macrophages</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenchyme</subject><subject>Middle Aged</subject><subject>Non-Hodgkin's lymphoma</subject><subject>Peripheral blood</subject><subject>Peripheral Blood Stem Cell Transplantation</subject><subject>Physiological aspects</subject><subject>Progenitor cells</subject><subject>Remission</subject><subject>Remission Induction</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Angiogenesis</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells - cytology</topic><topic>Bone marrow transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Care and treatment</topic><topic>Cell Lineage</topic><topic>Cells, Cultured - cytology</topic><topic>Chemotherapy</topic><topic>Colonies</topic><topic>Colony-Forming Units Assay</topic><topic>Combined Modality Therapy</topic><topic>Endothelial cells</topic><topic>Endothelial Cells - cytology</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hemopoiesis</topic><topic>Hodgkin's disease</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Immunosuppressive agents</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocytes (granulocytic)</topic><topic>Leukocytes (mononuclear)</topic><topic>Lymphoma</topic><topic>Lymphoma, Non-Hodgkin - drug therapy</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Lymphoma, Non-Hodgkin - therapy</topic><topic>Macrophages</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenchyme</topic><topic>Middle Aged</topic><topic>Non-Hodgkin's lymphoma</topic><topic>Peripheral blood</topic><topic>Peripheral Blood Stem Cell Transplantation</topic><topic>Physiological aspects</topic><topic>Progenitor cells</topic><topic>Remission</topic><topic>Remission Induction</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation</topic><topic>Transplantation, Autologous</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANZA, F</creatorcontrib><creatorcontrib>CAMPIONI, D</creatorcontrib><creatorcontrib>PUNTURIERI, M</creatorcontrib><creatorcontrib>MORETTI, S</creatorcontrib><creatorcontrib>DABUSTI, M</creatorcontrib><creatorcontrib>SPANEDDA, R</creatorcontrib><creatorcontrib>CASTOLDI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANZA, F</au><au>CAMPIONI, D</au><au>PUNTURIERI, M</au><au>MORETTI, S</au><au>DABUSTI, M</au><au>SPANEDDA, R</au><au>CASTOLDI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><addtitle>Bone Marrow Transplant</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>32</volume><issue>12</issue><spage>1165</spage><epage>1173</epage><pages>1165-1173</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>The distribution and functional characteristics of in vitro bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10(6) BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (P=0.04), and in normal subjects (P=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (P=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4-6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte-macrophage (CFU-GM) (P=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (P=0.044). These in vitro data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>14647271</pmid><doi>10.1038/sj.bmt.1704279</doi><tpages>9</tpages></addata></record> |
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| ispartof | Bone marrow transplantation (Basingstoke), 2003-12, Vol.32 (12), p.1165-1173 |
| issn | 0268-3369 1476-5365 |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers Bone marrow Bone Marrow Cells - cytology Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Cell Lineage Cells, Cultured - cytology Chemotherapy Colonies Colony-Forming Units Assay Combined Modality Therapy Endothelial cells Endothelial Cells - cytology Female Hematologic and hematopoietic diseases Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hemopoiesis Hodgkin's disease Humans Immunophenotyping Immunosuppressive agents Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes (granulocytic) Leukocytes (mononuclear) Lymphoma Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - pathology Lymphoma, Non-Hodgkin - therapy Macrophages Male Medical sciences Mesenchyme Middle Aged Non-Hodgkin's lymphoma Peripheral blood Peripheral Blood Stem Cell Transplantation Physiological aspects Progenitor cells Remission Remission Induction Stem cell transplantation Stem cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Autologous Transplantation, Homologous |
| title | In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation |
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