A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells

Cannabinoids activate several members of the mitogen-activated protein kinase superfamily including p44 and p42 extracellular signal-regulated kinase (ERK). We used N1E-115 neuroblastoma cells and the cannabinoid receptor agonist WIN 55,212-2 (WIN) to examine the signal transduction pathways leading...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (49), p.48973-48980
Hauptverfasser:	Davis, Margaret I., Ronesi, Jennifer, Lovinger, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclase Inhibitors Animals Benzoxazines Cell Line, Tumor Chromones - pharmacology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Enzyme Activation extracellular signal-regulated kinase Mice Mitogen-Activated Protein Kinases - metabolism Morpholines - pharmacology Naphthalenes - pharmacology Neuroblastoma - enzymology Neuroblastoma - pathology Phosphorylation Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - physiology
Online-Zugang:	Volltext
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