Growth factor expression and function in the human and mouse preimplantation embryo
There is increasing evidence that even before implantation, human development is regulated by embryonically and maternally derived growth factors. Studies in other mammalian species have shown that growth factors and their receptors are expressed by the preimplantation embryo and the reproductive tr...
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| Veröffentlicht in: | Journal of endocrinology 2002-02, Vol.172 (2), p.221-236 |
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| container_title | Journal of endocrinology |
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| creator | Hardy, K Spanos, S |
| description | There is increasing evidence that even before implantation, human development is regulated by embryonically and maternally derived growth factors. Studies in other mammalian species have shown that growth factors and their receptors are expressed by the preimplantation embryo and the reproductive tract. Furthermore, a number of growth factors have been shown to affect rate of embryo development, the proportion of embryos developing to the blastocyst stage, blastocyst cell number, metabolism and apoptosis. Growth factor ligands and receptors are also expressed in human embryos and the maternal reproductive tract, and supplementation of culture medium with exogenous growth factors affects cell fate, development and metabolism of human embryos in vitro. Autocrine, paracrine and endocrine pathways that may operate within the embryo and between the embryo and the reproductive tract before implantation are proposed. |
| doi_str_mv | 10.1677/joe.0.1720221 |
| format | Article |
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Studies in other mammalian species have shown that growth factors and their receptors are expressed by the preimplantation embryo and the reproductive tract. Furthermore, a number of growth factors have been shown to affect rate of embryo development, the proportion of embryos developing to the blastocyst stage, blastocyst cell number, metabolism and apoptosis. Growth factor ligands and receptors are also expressed in human embryos and the maternal reproductive tract, and supplementation of culture medium with exogenous growth factors affects cell fate, development and metabolism of human embryos in vitro. Autocrine, paracrine and endocrine pathways that may operate within the embryo and between the embryo and the reproductive tract before implantation are proposed.</description><identifier>ISSN: 0022-0795</identifier><identifier>EISSN: 1479-6805</identifier><identifier>DOI: 10.1677/joe.0.1720221</identifier><identifier>PMID: 11834440</identifier><identifier>CODEN: JOENAK</identifier><language>eng</language><publisher>Colchester: BioScientifica</publisher><subject>Animals ; Apoptosis - physiology ; Biological and medical sciences ; Blastocyst - metabolism ; Cell Culture Techniques ; Embryonic and Fetal Development - physiology ; Fallopian Tubes - metabolism ; Female ; Fertilization in Vitro ; Growth Substances - metabolism ; Humans ; Ligands ; Mammals - embryology ; Mammals - metabolism ; Mice ; Pregnancy ; Protein-Tyrosine Kinases - metabolism ; Receptors, Growth Factor - metabolism ; Signal Transduction - physiology</subject><ispartof>Journal of endocrinology, 2002-02, Vol.172 (2), p.221-236</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b513t-45223dc045912e1ef5cd43dc8cb9c65e0ce9f586946ecdbbe5b5fdfa8c9825bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13481605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11834440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hardy, K</creatorcontrib><creatorcontrib>Spanos, S</creatorcontrib><title>Growth factor expression and function in the human and mouse preimplantation embryo</title><title>Journal of endocrinology</title><addtitle>J Endocrinol</addtitle><description>There is increasing evidence that even before implantation, human development is regulated by embryonically and maternally derived growth factors. Studies in other mammalian species have shown that growth factors and their receptors are expressed by the preimplantation embryo and the reproductive tract. Furthermore, a number of growth factors have been shown to affect rate of embryo development, the proportion of embryos developing to the blastocyst stage, blastocyst cell number, metabolism and apoptosis. Growth factor ligands and receptors are also expressed in human embryos and the maternal reproductive tract, and supplementation of culture medium with exogenous growth factors affects cell fate, development and metabolism of human embryos in vitro. Autocrine, paracrine and endocrine pathways that may operate within the embryo and between the embryo and the reproductive tract before implantation are proposed.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - metabolism</subject><subject>Cell Culture Techniques</subject><subject>Embryonic and Fetal Development - physiology</subject><subject>Fallopian Tubes - metabolism</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Growth Substances - metabolism</subject><subject>Humans</subject><subject>Ligands</subject><subject>Mammals - embryology</subject><subject>Mammals - metabolism</subject><subject>Mice</subject><subject>Pregnancy</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Receptors, Growth Factor - metabolism</subject><subject>Signal Transduction - physiology</subject><issn>0022-0795</issn><issn>1479-6805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M9PwyAUB3BiNG5Oj15NL3rrhAL9cTSLTpMlHtRzA_RhWdYyoc3cfy-zTUxM9AQ8PjxevghdEjwnaZbdri3MwzZLcJKQIzQlLCviNMf8GE1xqMU4K_gEnXm_xphwktFTNCEkp4wxPEUvS2d3XR1poTrrIvjcOvDe2DYSbRXpvlXd4WDaqKshqvtGDDeN7T1EAZtmuxFtJ74ZNNLt7Tk60WLj4WJcZ-jt4f518RivnpdPi7tVLDmhXcx4ktBKYcYLkgABzVXFQiFXslApB6yg0DxPC5aCqqQELrmutMhVkSdcSjpDN0PfrbMfPfiubIxXsAnzQBivzAjjNKdpgPEAlbPeO9Dl1plGuH1JcHlIsQwplmE7pBj81di4lw1UP3qMLYDrEQivxEY70SrjfxxlOUkxD44Nrjbv9c44KKWxXhloO6ONEn_-T4dnv_T_U38BysSeuA</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Hardy, K</creator><creator>Spanos, S</creator><general>BioScientifica</general><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>Growth factor expression and function in the human and mouse preimplantation embryo</title><author>Hardy, K ; Spanos, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b513t-45223dc045912e1ef5cd43dc8cb9c65e0ce9f586946ecdbbe5b5fdfa8c9825bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - metabolism</topic><topic>Cell Culture Techniques</topic><topic>Embryonic and Fetal Development - physiology</topic><topic>Fallopian Tubes - metabolism</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Growth Substances - metabolism</topic><topic>Humans</topic><topic>Ligands</topic><topic>Mammals - embryology</topic><topic>Mammals - metabolism</topic><topic>Mice</topic><topic>Pregnancy</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Receptors, Growth Factor - metabolism</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardy, K</creatorcontrib><creatorcontrib>Spanos, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardy, K</au><au>Spanos, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth factor expression and function in the human and mouse preimplantation embryo</atitle><jtitle>Journal of endocrinology</jtitle><addtitle>J Endocrinol</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>172</volume><issue>2</issue><spage>221</spage><epage>236</epage><pages>221-236</pages><issn>0022-0795</issn><eissn>1479-6805</eissn><coden>JOENAK</coden><abstract>There is increasing evidence that even before implantation, human development is regulated by embryonically and maternally derived growth factors. 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| ispartof | Journal of endocrinology, 2002-02, Vol.172 (2), p.221-236 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Apoptosis - physiology Biological and medical sciences Blastocyst - metabolism Cell Culture Techniques Embryonic and Fetal Development - physiology Fallopian Tubes - metabolism Female Fertilization in Vitro Growth Substances - metabolism Humans Ligands Mammals - embryology Mammals - metabolism Mice Pregnancy Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - metabolism Signal Transduction - physiology |
| title | Growth factor expression and function in the human and mouse preimplantation embryo |
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