Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats
The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed...
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| Veröffentlicht in: | British journal of nutrition 2003-11, Vol.90 (5), p.953-960 |
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| creator | Iossa, Susanna Lionetti, Lillà Mollica, Maria P. Crescenzo, Raffaella Botta, Monica Barletta, Antonio Liverini, Giovanna |
| description | The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats. |
| doi_str_mv | 10.1079/BJN2003000968 |
| format | Article |
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The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN2003000968</identifier><identifier>PMID: 14667188</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>adults ; Animals ; Biological and medical sciences ; Blood Glucose - analysis ; blood serum ; Body Composition - physiology ; body fat ; Diet ; Dietary Fats - administration & dosage ; Energy ; Energy balance ; energy efficiency ; energy intake ; Energy Metabolism - physiology ; Fatty Acids, Nonesterified - blood ; Feeding ; Feeding. Feeding behavior ; Food ; Fundamental and applied biological sciences. Psychology ; high fat diet ; insulin ; Insulin - blood ; Leptin ; Leptin - blood ; Liver ; Liver - metabolism ; low fat diet ; Male ; Metabolism ; Mitochondria - metabolism ; Mitochondria, Liver - metabolism ; Mitochondria, Muscle - metabolism ; Mitochondrial capacity ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; nutrient partitioning ; Obesity ; Oxidation-Reduction ; Rats ; Rats, Wistar ; skeletal muscle ; Triiodothyronine ; Triiodothyronine - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weaning</subject><ispartof>British journal of nutrition, 2003-11, Vol.90 (5), p.953-960</ispartof><rights>Copyright © The Nutrition Society 2003</rights><rights>2004 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-308f52d97770883f3cd10c9e18fb7e0dfe711ae697775cd9853e613c4fee5df33</citedby><cites>FETCH-LOGICAL-c558t-308f52d97770883f3cd10c9e18fb7e0dfe711ae697775cd9853e613c4fee5df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15198794$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14667188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iossa, Susanna</creatorcontrib><creatorcontrib>Lionetti, Lillà</creatorcontrib><creatorcontrib>Mollica, Maria P.</creatorcontrib><creatorcontrib>Crescenzo, Raffaella</creatorcontrib><creatorcontrib>Botta, Monica</creatorcontrib><creatorcontrib>Barletta, Antonio</creatorcontrib><creatorcontrib>Liverini, Giovanna</creatorcontrib><title>Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.</description><subject>adults</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>blood serum</subject><subject>Body Composition - physiology</subject><subject>body fat</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Energy</subject><subject>Energy balance</subject><subject>energy efficiency</subject><subject>energy intake</subject><subject>Energy Metabolism - physiology</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Feeding</subject><subject>Feeding. Feeding behavior</subject><subject>Food</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>high fat diet</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>low fat diet</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria, Liver - metabolism</subject><subject>Mitochondria, Muscle - metabolism</subject><subject>Mitochondrial capacity</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Musculoskeletal system</subject><subject>nutrient partitioning</subject><subject>Obesity</subject><subject>Oxidation-Reduction</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>skeletal muscle</subject><subject>Triiodothyronine</subject><subject>Triiodothyronine - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weaning</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0M9vFCEUB_CJ0di1evSqxERvY2EYfsxRN7X-2NQY24sXwsJjlzozrMCY7n8vdSduNB4IAT55vO-rqqcEvyZYdGdvP142GFOMccflvWpBWsHqhvPmfrUol6ImpGUn1aOUbspREtw9rE5Iy7kgUi4qOHcOTEbBoa3fbGunM3IA1o8bFEY0QNbr0HuDwDlvPIxmj_Ro0eBzMNsw2uh1j8Kttzr7n4CM3mnj8x75EWk79RlFndPj6oHTfYIn835aXb87v1q-r1efLz4s36xqw5jMNcXSscZ2QggsJXXUWIJNB0S6tQBsHQhCNPA7wIztJKPACTVt6ZhZR-lp9epQdxfDjwlSVoNPBvpejxCmpESZBaWUFPjiH3gTpjiW3lRDqKS0o6yg-oBMDClFcGoX_aDjXhGs7oav_hp-8c_motN6AHvU87QLeDkDnYzuXdSj8enoGOmk6Nrjxz5luP3zruN3xQUVTPGLL2r5ibDLq9U3xYt_fvBOB6U3sdS8_tpg0uKyGvk779kcRQ_r6O0GjoH_H-YXK9GyaQ</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Iossa, Susanna</creator><creator>Lionetti, Lillà</creator><creator>Mollica, Maria P.</creator><creator>Crescenzo, Raffaella</creator><creator>Botta, Monica</creator><creator>Barletta, Antonio</creator><creator>Liverini, Giovanna</creator><general>Cambridge University Press</general><general>CABI Pub</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats</title><author>Iossa, Susanna ; Lionetti, Lillà ; Mollica, Maria P. ; Crescenzo, Raffaella ; Botta, Monica ; Barletta, Antonio ; Liverini, Giovanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-308f52d97770883f3cd10c9e18fb7e0dfe711ae697775cd9853e613c4fee5df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>adults</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>blood serum</topic><topic>Body Composition - physiology</topic><topic>body fat</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>Energy</topic><topic>Energy balance</topic><topic>energy efficiency</topic><topic>energy intake</topic><topic>Energy Metabolism - physiology</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Feeding</topic><topic>Feeding. Feeding behavior</topic><topic>Food</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>high fat diet</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>low fat diet</topic><topic>Male</topic><topic>Metabolism</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondria, Liver - metabolism</topic><topic>Mitochondria, Muscle - metabolism</topic><topic>Mitochondrial capacity</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Musculoskeletal system</topic><topic>nutrient partitioning</topic><topic>Obesity</topic><topic>Oxidation-Reduction</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>skeletal muscle</topic><topic>Triiodothyronine</topic><topic>Triiodothyronine - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iossa, Susanna</creatorcontrib><creatorcontrib>Lionetti, Lillà</creatorcontrib><creatorcontrib>Mollica, Maria P.</creatorcontrib><creatorcontrib>Crescenzo, Raffaella</creatorcontrib><creatorcontrib>Botta, Monica</creatorcontrib><creatorcontrib>Barletta, Antonio</creatorcontrib><creatorcontrib>Liverini, Giovanna</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iossa, Susanna</au><au>Lionetti, Lillà</au><au>Mollica, Maria P.</au><au>Crescenzo, Raffaella</au><au>Botta, Monica</au><au>Barletta, Antonio</au><au>Liverini, Giovanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>90</volume><issue>5</issue><spage>953</spage><epage>960</epage><pages>953-960</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>14667188</pmid><doi>10.1079/BJN2003000968</doi><tpages>8</tpages></addata></record> |
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| subjects | adults Animals Biological and medical sciences Blood Glucose - analysis blood serum Body Composition - physiology body fat Diet Dietary Fats - administration & dosage Energy Energy balance energy efficiency energy intake Energy Metabolism - physiology Fatty Acids, Nonesterified - blood Feeding Feeding. Feeding behavior Food Fundamental and applied biological sciences. Psychology high fat diet insulin Insulin - blood Leptin Leptin - blood Liver Liver - metabolism low fat diet Male Metabolism Mitochondria - metabolism Mitochondria, Liver - metabolism Mitochondria, Muscle - metabolism Mitochondrial capacity Muscle, Skeletal - metabolism Musculoskeletal system nutrient partitioning Obesity Oxidation-Reduction Rats Rats, Wistar skeletal muscle Triiodothyronine Triiodothyronine - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Weaning |
| title | Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats |
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