The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6

The paired-homeobox genes pax-4 and pax-6 are crucial for islet development; whereas the null mutation of pax-6 results in the nearly absence of glucagon-producing alpha cells, pax-4 homozygous mutant mice lack insulin and somatostatin-producing beta and delta cells but contain an increased number o...

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