Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury

Basic fibroblast growth factor (or FGF-2) has been shown to be a potent stimulator of retinal ganglion cell (RGC) axonal growth during development. Here we investigated if FGF-2 upregulation in adult RGCs promoted axon regrowth in vivo after acute optic nerve injury. Recombinant adeno-associated vir...

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Veröffentlicht in:	Molecular and cellular neuroscience 2003-11, Vol.24 (3), p.656-672
Hauptverfasser:	Sapieha, Przemyslaw S, Peltier, Martin, Rendahl, Katherine G, Manning, William C, Di Polo, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Survival - genetics Disease Models, Animal Female Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - physiology Gene Expression Regulation, Developmental - genetics Gene Transfer Techniques Genetic Therapy Genetic Vectors - genetics Genetic Vectors - pharmacology Genetic Vectors - therapeutic use Growth Cones - metabolism Growth Cones - ultrastructure Heparitin Sulfate - metabolism Nerve Regeneration - drug effects Nerve Regeneration - genetics Optic Nerve Injuries - metabolism Optic Nerve Injuries - physiopathology Optic Nerve Injuries - therapy Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases - drug effects Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - drug effects Receptors, Fibroblast Growth Factor - metabolism Retina - cytology Retina - growth & development Retina - metabolism Retinal Ganglion Cells - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Up-Regulation - genetics
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