Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia
The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have be...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2002-03, Vol.23 (3), p.507-514 |
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| creator | Pokabla, M J Dickerson, I M Papka, R E |
| description | The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cellular identification of the CGRP receptor has received little attention. CGRP-receptor component protein (CGRP-RCP) is a small protein associated with the CGRP receptor; thus, immunostaining for the CGRP-RCP can be used to identify sites of the CGRP receptor. We determined sites of CGRP-RCP immunoreactivity relative to the presence of CGRP-ir nerve fibers in the female rat uterine cervix, spinal cord, and dorsal root ganglia. CGRP-RCP immunoreactivity was expressed in the dorsal horn of the spinal cord, venules of the uterine cervix, and perikarya of sensory neurons in dorsal root ganglia. CGRP-immunoreactive fibers were adjacent to CGRP-RCP-immunoreactive vessels in the cervix and among CGRP-RCP-immunoreactive structures in the dorsal horn of the spinal cord. This suggests CGRP-RCP is associated with structures innervated by CGRP nerves and these interactions may be changed in tissues in response to an appropriate stimulus. |
| doi_str_mv | 10.1016/S0196-9781(01)00638-6 |
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CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cellular identification of the CGRP receptor has received little attention. CGRP-receptor component protein (CGRP-RCP) is a small protein associated with the CGRP receptor; thus, immunostaining for the CGRP-RCP can be used to identify sites of the CGRP receptor. We determined sites of CGRP-RCP immunoreactivity relative to the presence of CGRP-ir nerve fibers in the female rat uterine cervix, spinal cord, and dorsal root ganglia. CGRP-RCP immunoreactivity was expressed in the dorsal horn of the spinal cord, venules of the uterine cervix, and perikarya of sensory neurons in dorsal root ganglia. CGRP-immunoreactive fibers were adjacent to CGRP-RCP-immunoreactive vessels in the cervix and among CGRP-RCP-immunoreactive structures in the dorsal horn of the spinal cord. This suggests CGRP-RCP is associated with structures innervated by CGRP nerves and these interactions may be changed in tissues in response to an appropriate stimulus.</description><identifier>ISSN: 0196-9781</identifier><identifier>DOI: 10.1016/S0196-9781(01)00638-6</identifier><identifier>PMID: 11836000</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cervix Uteri - metabolism ; Female ; Ganglia, Spinal - metabolism ; Lumbosacral Region ; Rats ; Rats, Sprague-Dawley ; Receptors, Calcitonin Gene-Related Peptide - biosynthesis ; Receptors, Calcitonin Gene-Related Peptide - immunology ; Receptors, Calcitonin Gene-Related Peptide - metabolism ; Spinal Cord - metabolism ; Uterus - metabolism</subject><ispartof>Peptides (New York, N.Y. : 1980), 2002-03, Vol.23 (3), p.507-514</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-c385cb1efc535c01c4039b02f9fba74ac120b0b98e0851ea181864de25f2f5b93</citedby><cites>FETCH-LOGICAL-c305t-c385cb1efc535c01c4039b02f9fba74ac120b0b98e0851ea181864de25f2f5b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11836000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pokabla, M J</creatorcontrib><creatorcontrib>Dickerson, I M</creatorcontrib><creatorcontrib>Papka, R E</creatorcontrib><title>Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cellular identification of the CGRP receptor has received little attention. CGRP-receptor component protein (CGRP-RCP) is a small protein associated with the CGRP receptor; thus, immunostaining for the CGRP-RCP can be used to identify sites of the CGRP receptor. We determined sites of CGRP-RCP immunoreactivity relative to the presence of CGRP-ir nerve fibers in the female rat uterine cervix, spinal cord, and dorsal root ganglia. CGRP-RCP immunoreactivity was expressed in the dorsal horn of the spinal cord, venules of the uterine cervix, and perikarya of sensory neurons in dorsal root ganglia. CGRP-immunoreactive fibers were adjacent to CGRP-RCP-immunoreactive vessels in the cervix and among CGRP-RCP-immunoreactive structures in the dorsal horn of the spinal cord. This suggests CGRP-RCP is associated with structures innervated by CGRP nerves and these interactions may be changed in tissues in response to an appropriate stimulus.</description><subject>Animals</subject><subject>Cervix Uteri - metabolism</subject><subject>Female</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Lumbosacral Region</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Calcitonin Gene-Related Peptide - biosynthesis</subject><subject>Receptors, Calcitonin Gene-Related Peptide - immunology</subject><subject>Receptors, Calcitonin Gene-Related Peptide - metabolism</subject><subject>Spinal Cord - metabolism</subject><subject>Uterus - metabolism</subject><issn>0196-9781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFO3TAQRb1oBRT4hCKvUJFImUniPGeJnqCthNRFy9pynMnDKLGD7SD6Ef1nHHhqJcszd3TvWD6MfUb4ioDN1S_AtinajcQvgBcATSWL5gM7-jc-ZJ9ifASAum7lATtElFWT5RH7u9Wjsck76_iOHBWBRp2o5zPNyfarNrnzgRs_zd6RS3wOPlH208scKEbrHc8qPRBfEgXriBsKz_blko_L1PmoTdAjj7N1uRgf-kuuXc97H2IeBO8T32m3G60-YR8HPUY63ddjdn9783v7vbj7-e3H9vquMBWIlG8pTIc0GFEJA2hqqNoOyqEdOr2ptcESOuhaSSAFkkaJsql7KsVQDqJrq2N2_r43f-VpoZjUZKOhcdSO_BLVBmuBUK5G8W40wccYaFBzsJMOfxSCWtmrN_Zqhawgn5W9anLubP_A0k3U_0_twVevSbOFLg</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Pokabla, M J</creator><creator>Dickerson, I M</creator><creator>Papka, R E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia</title><author>Pokabla, M J ; Dickerson, I M ; Papka, R E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-c385cb1efc535c01c4039b02f9fba74ac120b0b98e0851ea181864de25f2f5b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cervix Uteri - metabolism</topic><topic>Female</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Lumbosacral Region</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Calcitonin Gene-Related Peptide - biosynthesis</topic><topic>Receptors, Calcitonin Gene-Related Peptide - immunology</topic><topic>Receptors, Calcitonin Gene-Related Peptide - metabolism</topic><topic>Spinal Cord - metabolism</topic><topic>Uterus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pokabla, M J</creatorcontrib><creatorcontrib>Dickerson, I M</creatorcontrib><creatorcontrib>Papka, R E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pokabla, M J</au><au>Dickerson, I M</au><au>Papka, R E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>23</volume><issue>3</issue><spage>507</spage><epage>514</epage><pages>507-514</pages><issn>0196-9781</issn><abstract>The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cellular identification of the CGRP receptor has received little attention. CGRP-receptor component protein (CGRP-RCP) is a small protein associated with the CGRP receptor; thus, immunostaining for the CGRP-RCP can be used to identify sites of the CGRP receptor. We determined sites of CGRP-RCP immunoreactivity relative to the presence of CGRP-ir nerve fibers in the female rat uterine cervix, spinal cord, and dorsal root ganglia. CGRP-RCP immunoreactivity was expressed in the dorsal horn of the spinal cord, venules of the uterine cervix, and perikarya of sensory neurons in dorsal root ganglia. CGRP-immunoreactive fibers were adjacent to CGRP-RCP-immunoreactive vessels in the cervix and among CGRP-RCP-immunoreactive structures in the dorsal horn of the spinal cord. This suggests CGRP-RCP is associated with structures innervated by CGRP nerves and these interactions may be changed in tissues in response to an appropriate stimulus.</abstract><cop>United States</cop><pmid>11836000</pmid><doi>10.1016/S0196-9781(01)00638-6</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2002-03, Vol.23 (3), p.507-514 |
| issn | 0196-9781 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cervix Uteri - metabolism Female Ganglia, Spinal - metabolism Lumbosacral Region Rats Rats, Sprague-Dawley Receptors, Calcitonin Gene-Related Peptide - biosynthesis Receptors, Calcitonin Gene-Related Peptide - immunology Receptors, Calcitonin Gene-Related Peptide - metabolism Spinal Cord - metabolism Uterus - metabolism |
| title | Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia |
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